Haplotypic polymorphisms and forensic applications in Chinese Hunan Han population based on a series of Y-STR loci: a perspective of paternal inheritance.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2171120

Ming Zhao, Wei Cui, Yunying Zhang, Qiong Lan, Bofeng Zhu

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引用次数: 0

Abstract

Background: Hunan, a multinational province in China, possesses more than fifty ethnic groups, such as the Han, Yao, Tujia, Miao, and so on.

Aims: To evaluate the forensic efficiency of the novel panel and investigate the genetic relationships between Hunan Han population and 12 other reference populations from China.

Subjects and methods: Haplotypic data of 153 unrelated males of Hunan Han population were investigated using the AGCU Y SUPP Plus amplification system containing 27 Y-chromosomal short tandem repeat (STR) loci. Forensic parameters were calculated to evaluate the application efficiency of this panel in Hunan Han population.

Results: Haplotype diversity, discrimination capability, and match probability values were 0.9999999977, 1.0000, and 0.0065, respectively. Pairwise fixation index values demonstrated that the minimal genetic differentiation (0.0073) was found between Hunan Han population and Hunan Yao group, while the maximal genetic differentiation (0.0651) was observed between Hunan Han and Guangxi Yao group from the perspective of the patrilineal DNA analysis.

Conclusions: The haplotype distributions of 27 Y-STR loci in Hunan Han population exhibited remarkable polymorphisms. Moreover, this panel has potential advantages for the forensic applications regarding family investigations, paternity testing of the paternal line, and population genetics.

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基于一系列Y-STR位点的中国湖南汉族人群单倍型多态性及其法医学应用:父系遗传的视角

背景:湖南是中国的一个多民族省份，有汉族、瑶族、土家族、苗族等五十多个民族。目的:评价新群体的法医学鉴定效率，探讨湖南汉族群体与中国其他12个参考群体的遗传关系。对象与方法:采用AGCU Y SUPP Plus基因扩增系统对153名湖南汉族无亲缘关系男性进行单倍型分析，该系统包含27个Y染色体短串联重复(STR)位点。计算法医学参数，评价该面板在湖南汉族人群中的应用效率。结果:单倍型多样性值为0.9999999977，辨别能力值为1.0000，匹配概率值为0.0065。父系DNA分析结果显示，湖南汉族群体与湖南瑶族群体的遗传分化最小(0.0073)，而湖南汉族与广西瑶族群体的遗传分化最大(0.0651)。结论:湖南汉族人群27个Y-STR基因座单倍型分布具有显著的多态性。此外，该小组在家庭调查，父系亲子鉴定和群体遗传学的法医应用方面具有潜在的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.