The effects of acute normobaric hypoxia on vestibular-evoked balance responses in humans.

IF 2.9 3区医学 Q2 NEUROSCIENCES

Journal of Vestibular Research-Equilibrium & Orientation Pub Date : 2023-01-01 DOI:10.3233/VES-220075

M I B Debenham, T D A Grantham, J D Smirl, G E Foster, B H Dalton

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引用次数: 1

Abstract

Background: Hypoxia influences standing balance and vestibular function.

Objective: The purpose here was to investigate the effect of hypoxia on the vestibular control of balance.

Methods: Twenty participants (10 males; 10 females) were tested over two days (normobaric hypoxia and normoxia). Participants stood on a force plate (head rotated leftward) and experienced random, continuous electrical vestibular stimulation (EVS) during trials of eyes open (EO) and closed (EC) at baseline (BL), after 5 (H1), 30 (H2) and 55-min (H3) of hypoxia, and 10-min into normoxic recovery (NR). Vestibular-evoked balance responses were quantified using cumulant density, coherence, and gain functions between EVS and anteroposterior forces.

Results: Oxyhemoglobin saturation, end-tidal oxygen and carbon dioxide decreased for H1-3 compared to BL; however, end-tidal carbon dioxide remained reduced at NR with EC (p≤0.003). EVS-AP force peak-to-peak amplitude was lower at H3 and NR than at BL (p≤0.01). At multiple frequencies, EVS-AP force coherence and gain estimates were lower at H3 and NR than BL for females; however, this was only observed for coherence for males.

Conclusions: Overall, vestibular-evoked balance responses are blunted following normobaric hypoxia >30 min, which persists into NR and may contribute to the reported increases in postural sway.

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急性常压缺氧对人类前庭诱发平衡反应的影响。

背景:缺氧影响站立平衡和前庭功能。目的:探讨缺氧对前庭平衡控制的影响。方法:20例受试者(男性10例;10名女性)进行了为期两天的测试(常压缺氧和常压缺氧)。参与者站在一个力板上(头部向左旋转)，在基线(BL)的睁眼(EO)和闭眼(EC)试验中，在缺氧5 (H1)、30 (H2)和55分钟(H3)后，以及10分钟进入常氧恢复(NR)后，经历随机、连续的前庭电刺激(EVS)。前庭诱发平衡反应通过ev和前后力之间的累积密度、相干性和增益函数进行量化。结果:H1-3组与BL组相比，血红蛋白饱和度、潮末氧、二氧化碳含量降低;然而，随着EC的增加，潮末二氧化碳仍然减少(p≤0.003)。H3和NR组EVS-AP力峰幅值低于BL组(p≤0.01)。在多个频率下，女性在H3和NR时的ev - ap力相干性和增益估计值低于BL;然而，这只观察到男性的一致性。结论:总的来说，在常压缺氧>30分钟后，前庭诱发的平衡反应变得迟钝，这种反应持续到NR，并可能导致体位摇摆的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vestibular Research-Equilibrium & Orientation 医学-耳鼻喉科学

CiteScore

5.00

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Vestibular Research is a peer-reviewed journal that publishes experimental and observational studies, review papers, and theoretical papers based on current knowledge of the vestibular system. Subjects of the studies can include experimental animals, normal humans, and humans with vestibular or other related disorders. Study topics can include the following: Anatomy of the vestibular system, including vestibulo-ocular, vestibulo-spinal, and vestibulo-autonomic pathways Balance disorders Neurochemistry and neuropharmacology of balance, both at the systems and single neuron level Neurophysiology of balance, including the vestibular, ocular motor, autonomic, and postural control systems Psychophysics of spatial orientation Space and motion sickness Vestibular rehabilitation Vestibular-related human performance in various environments