Establishing a molecular laboratory in COVID-19 pandemic: The experience of a regional laboratory in Spain.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-02 DOI:10.1556/030.2023.01972

Zaira Moure, Elena Cuadros, Daniel Pablo-Marcos, María José Reina, Inés de Benito, Ana Belén Campo

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Abstract

The high demand for COVID-19 diagnosis overwhelmed reference hospitals. Regional laboratories had to incorporate molecular technology to respond to the emergency. This work described the implementation of molecular diagnostic tools and the detection of SARS-CoV-2, in a regional hospital with no previous experience, from October 2020 to March 2022. The laboratory structure was significantly modified. The staff grew from 3 to 4 clinical microbiologists, and from 7 to 17 laboratory technicians to provide 24/7 coverage. A total of 144,442 samples were processed during the period of study. The highest peaks were reached in July 2021 with 25,285 samples processed, and between December 2021 and January 2022, with 32,245. COVID-19 pandemic has represented not only the challenge, but the opportunity to introduce Nucleic Acid Amplification Techniques (NAAT) in inexperienced laboratories. These secondary settings have shown an extraordinary ability to adapt and cannot be left behind in the progress of diagnostic techniques.

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在COVID-19大流行中建立分子实验室:西班牙区域实验室的经验。

COVID-19诊断的高需求使参考医院不堪重负。区域实验室必须采用分子技术来应对紧急情况。这项工作描述了从2020年10月到2022年3月，在一家以前没有经验的地区医院实施分子诊断工具和检测SARS-CoV-2。实验室结构有了明显的改变。工作人员从3名临床微生物学家增加到4名，从7名实验室技术人员增加到17名，提供全天候服务。研究期间共处理了144442份样本。2021年7月达到峰值，处理了25,285个样本，2021年12月至2022年1月期间，处理了32,245个样本。COVID-19大流行不仅是挑战，也是在缺乏经验的实验室引入核酸扩增技术(NAAT)的机会。这些次要环境显示出非凡的适应能力，在诊断技术的进步中不能落后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.