The role of extracellular ATP in homeostatic immune cell migration

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2023-02-01 DOI:10.1016/j.coph.2022.102331

Daichi Kobayashi , Eiji Umemoto , Masayuki Miyasaka

引用次数: 1

Abstract

Antigen stimulation induces adenosine triphosphate (ATP) release from naïve lymphocytes in lymphoid tissues. However, previous studies indicated that the non-lytic release of ATP also occurs in most tissues and cell types under physiological conditions. Here, we show that extracellular ATP (eATP) is indeed constitutively produced by naïve T cells in response to lymphoid chemokines in uninflamed lymph nodes and is involved in the regulation of immune cell migration. In this review, we briefly summarize the homeostatic role of extracellular ATP in immune cell migration in vivo.

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细胞外ATP在稳态免疫细胞迁移中的作用

抗原刺激诱导淋巴组织中幼稚淋巴细胞释放三磷酸腺苷（ATP）。然而，先前的研究表明，在生理条件下，ATP的非溶解性释放也发生在大多数组织和细胞类型中。在这里，我们发现细胞外ATP（eATP）确实是由幼稚的T细胞组成性地产生的，以响应未炎症淋巴结中的淋巴趋化因子，并参与免疫细胞迁移的调节。在这篇综述中，我们简要总结了细胞外ATP在体内免疫细胞迁移中的稳态作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.