Is There An Association Between Periodontitis And Non-Alcoholic Fatty Liver Disease? A Systematic Review and Meta-Analysis.

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Community dental health Pub Date : 2023-02-28 DOI:10.1922/CDH_00180Xu06

F Xu, J Tang

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引用次数: 2

Abstract

Background: Studies have reported varying relationships between periodontitis and non-alcoholic fatty liver disease (NAFLD). This review aimed to summarise evidence by pooling published data on the association between periodontitis and NAFLD.

Methods: PubMed, CENTRAL, Web of Science, and Embase databases were searched for cross-sectional, case-control, or cohort studies published up to 20th June 2022. The PICO statement was: In the general Population does the presence of periodontitis (Intervention) as compared to no periodontitis (Comparison) lead to NAFLD (Outcome). All included studies were to report the association between periodontitis and NAFLD using odds ratios (OR) or risk ratios with 95% confidence intervals (CI). Random effects meta-analysis was conducted to obtain pooled OR with 95% CI.

Results: Meta-analysis of seven studies with data of 192,815 participants found no association between periodontitis and NAFLD (OR: 1.04 95% CI: 0.97, 1.12). There was medium heterogeneity in the meta-analysis (I²=58%). The results did not change with the exclusion of any study. A small risk of NAFLD was noted in periodontitis patients on analysis of two cohort studies. Results were non-significant for other study types. Subgroup analysis based on the study population and diagnostic method for NAFLD also failed to find relationships.

Conclusion: Current evidence fails to demonstrate a link between periodontitis and NAFLD.

查看原文本刊更多论文

牙周炎与非酒精性脂肪肝有关联吗?系统回顾和荟萃分析。

背景:研究报道了牙周炎和非酒精性脂肪性肝病(NAFLD)之间的不同关系。本综述旨在通过汇集已发表的关于牙周炎和NAFLD之间关联的数据来总结证据。方法:检索PubMed、CENTRAL、Web of Science和Embase数据库，检索截至2022年6月20日发表的横断面、病例对照或队列研究。PICO声明是:在一般人群中，与没有牙周炎(比较)相比，牙周炎的存在是否会导致NAFLD(结果)。所有纳入的研究均采用比值比(OR)或95%可信区间(CI)的风险比报告牙周炎和NAFLD之间的关联。随机效应荟萃分析获得95% CI的合并OR。结果:对7项研究192,815名参与者的荟萃分析发现牙周炎和NAFLD之间没有关联(OR: 1.04 95% CI: 0.97, 1.12)。meta分析中存在中等异质性(I²=58%)。排除任何研究后，结果没有改变。两项队列研究的分析表明，牙周炎患者发生NAFLD的风险较小。其他研究类型的结果无显著性。基于研究人群和NAFLD诊断方法的亚组分析也未能发现两者之间的关系。结论:目前的证据不能证明牙周炎和NAFLD之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.