Mapping and ablation of ventricular fibrillation substrate.

IF 2.7 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Interventional Cardiac Electrophysiology Pub Date : 2026-08-01 Epub Date: 2023-01-04 DOI:10.1007/s10840-022-01454-z

Fatima M Ezzeddine, Robert Charles Ward, Samuel J Asirvatham, Christopher V DeSimone

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引用次数: 0

Abstract

Ventricular fibrillation (VF) is a life-threatening arrhythmia and a common cause of sudden cardiac death (SCD). A basic understanding of its mechanistic underpinning is crucial for enhancing our knowledge to develop innovative mapping and ablation techniques for this lethal rhythm. Significant advances in our understanding of VF have been made especially in the basic science and pre-clinical experimental realms. However, these studies have not yet translated into a robust clinical approach to identify and successfully ablate both the structural and functional substrate of VF. In this review, we aim to (1) provide a conceptual framework of VF and an overview of the data supporting the spatiotemporal dynamics of VF, (2) review experimental approaches to mapping VF to elucidate drivers and substrate for maintenance with a focus on the His-Purkinje system, (3) discuss current approaches using catheter ablation to treat VF, and (4) highlight current unknowns and gaps in the field where future work is necessary to transform the clinical landscape.

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绘制和消融心室颤动基质。

心室颤动（VF）是一种危及生命的心律失常，也是心脏性猝死（SCD）的常见原因。对其机理基础的基本了解对于增强我们的知识、开发针对这种致命心律的创新性绘图和消融技术至关重要。我们对室颤的认识取得了重大进展，尤其是在基础科学和临床前实验领域。然而，这些研究尚未转化为可靠的临床方法来识别并成功消融室颤的结构和功能基底。在这篇综述中，我们旨在：（1）提供室颤的概念框架和支持室颤时空动态的数据概览；（2）回顾绘制室颤图的实验方法，以阐明维持室颤的驱动因素和基质，重点关注 His-Purkinje 系统；（3）讨论目前使用导管消融治疗室颤的方法；以及（4）强调该领域目前存在的未知因素和差距，未来有必要在这些方面开展工作，以改变临床现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Interventional Cardiac Electrophysiology 医学-心血管系统

CiteScore

4.30

自引率

11.10%

发文量

320

审稿时长

4-8 weeks

期刊介绍： The Journal of Interventional Cardiac Electrophysiology is an international publication devoted to fostering research in and development of interventional techniques and therapies for the management of cardiac arrhythmias. It is designed primarily to present original research studies and scholarly scientific reviews of basic and applied science and clinical research in this field. The Journal will adopt a multidisciplinary approach to link physical, experimental, and clinical sciences as applied to the development of and practice in interventional electrophysiology. The Journal will examine techniques ranging from molecular, chemical and pharmacologic therapies to device and ablation technology. Accordingly, original research in clinical, epidemiologic and basic science arenas will be considered for publication. Applied engineering or physical science studies pertaining to interventional electrophysiology will be encouraged. The Journal is committed to providing comprehensive and detailed treatment of major interventional therapies and innovative techniques in a structured and clinically relevant manner. It is directed at clinical practitioners and investigators in the rapidly growing field of interventional electrophysiology. The editorial staff and board reflect this bias and include noted international experts in this area with a wealth of expertise in basic and clinical investigation. Peer review of all submissions, conflict of interest guidelines and periodic editorial board review of all Journal policies have been established.