The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes.

IF 2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xiao Jie Wang, Xue Bai, Ying Miu, Pan Chen, Pi Jun Yan, Chun Xia Jiang
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引用次数: 0

Abstract

Background: This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.

Methods: From January 2019 to June 2021, 79 cases of POP patients were selected as the research objects. A test of the patients' bone density was conducted, and clinical grading of POP was via T value (normal, mild, moderate, severe). The analysis of the assessment value of pathological condition of serum APN and amylin for POP and their association with bone metabolism indexes in patients was performed.

Results: APN and amylin in patients were declined with POP's aggravation. APN of 5.15 μg/mL or less and amylin of 15.38 pmol/L or less were risk factors influencing the aggravation of pathological condition of POP (P< 0 .0 5). The area under the curve (AUC) of combined detection of APN and amylin to assess the severity of POP was elevated vs. alone test of amylin (P< 0.05). 25-hydroxyvitamin D (25-(OH) D) and total type 1 procollagen amino-terminal propeptide (t-PINP) in patients were descended with the aggravation of pathological condition of osteoporosis (P < 0.05). At the same time, no distinct differences were presented in the three groups of type I collagen hydroxyl terminal peptide b degradation product (β-CTX) and N-terminal osteocalcin (N-MID) (P> 0.05). APN, amylin, 25-(OH)D, β-CTX, and t-PINP were negatively linked with POP clinical grade (P< 0.05). APN and amylin were associated with 25-(OH) D, β-CTX, t-PINP (P< 0.05), and APN and amylin were not linked with N-MID (P> 0.05).

Conclusions: Serum APN and amylin are provided with evaluation values for the severity of POP and are associated with bone metabolism in patients.

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血清脂联素、胰淀素病理状态在原发性骨质疏松症中的评价价值及其与骨代谢指标的相关性分析。
背景:探讨血清脂联素(APN)和胰淀素(amylin)病理状态在原发性骨质疏松症(POP)中的评价价值及其与骨代谢指标的相关性。方法:选取2019年1月~ 2021年6月79例POP患者作为研究对象。对患者进行骨密度检测,通过T值对POP进行临床分级(正常、轻度、中度、重度)。分析患者血清APN和胰淀素病理状态对POP的评估价值及其与骨代谢指标的相关性。结果:随着POP的加重,APN和胰淀素呈下降趋势。APN为5.15 μg/mL及以下、amylin为15.38 pmol/L及以下是影响POP病理状况加重的危险因素(P< 0.05),联合检测APN和amylin评估POP严重程度的曲线下面积(AUC)较单独检测amylin升高(P< 0.05)。25-羟基维生素D (25-(OH) D)和总1型前胶原氨基末端前肽(t-PINP)随骨质疏松病理状况的加重而下降(P < 0.05)。同时,三组ⅰ型胶原羟基末端肽b降解产物(β-CTX)和n端骨钙素(N-MID)均无显著差异(P> 0.05)。APN、胰淀素、25-(OH)D、β-CTX、t-PINP与POP临床分级呈负相关(P< 0.05)。APN和amylin与25-(OH) D、β-CTX、t-PINP相关(P< 0.05),而APN和amylin与N-MID无关(P> 0.05)。结论:血清APN和胰淀素对POP的严重程度具有评价价值,并与患者骨代谢有关。
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来源期刊
Journal of Medical Biochemistry
Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.00
自引率
12.00%
发文量
60
审稿时长
>12 weeks
期刊介绍: The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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