Hydrogen applications: advances in the field of medical therapy.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Gas Research Pub Date : 2023-07-01 DOI:10.4103/2045-9912.344978

Tao Yuan, Jian-Ning Zhao, Ni-Rong Bao

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引用次数: 2

Abstract

Hydrogen (H₂) has been widely used in the chemical industry as a reducing agent. As the researches move along, increasing attention has been paid to its biological functions. The selective antioxidant effect of hydrogen is considered to be the main reason for medical applications. So far, many studies have confirmed its potential protective effects on ischemia/reperfusion injury of multiple organs, neurodegenerative diseases, bone and joint diseases, and respiratory diseases, opening a new era in the medical research and application of H₂. Increasing studies have focused on its biological effects and molecular mechanisms in the treatment of different diseases. In this paper, we review the biological effects, molecular mechanisms and methods of H₂ supply. We do hope that the advances in materials science can be better translated into medical applications and solve clinical problems. The medical application of H₂ is promising, and how to prepare an H₂ sustained-release system to achieve a sustained and stable H₂ supply in the body and ultimately improve the therapeutic effect of H₂ is a problem worthy of further investigation.

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氢的应用:医学治疗领域的进展。

氢(H2)作为还原剂在化学工业中得到了广泛的应用。随着研究的深入，其生物学功能越来越受到人们的关注。氢的选择性抗氧化作用被认为是其在医学上应用的主要原因。迄今为止，许多研究证实了其对多器官缺血再灌注损伤、神经退行性疾病、骨关节疾病、呼吸系统疾病的潜在保护作用，开启了H2的医学研究和应用的新时代。越来越多的研究集中在其治疗不同疾病的生物学效应和分子机制上。本文就植物供氢的生物学效应、分子机制和方法作一综述。我们希望材料科学的进步能够更好地转化为医学应用，解决临床问题。H2的医学应用前景广阔，如何制备H2缓释体系，实现体内持续稳定的H2供应，最终提高H2的治疗效果是一个值得进一步研究的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.10

自引率

13.80%

发文量

期刊介绍： Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.