The Efficacy of Surgical Resection versus Radiofrequency Ablation for the Treatment of Single Hepatocellular Carcinoma: A SEER-Based Study.

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Research and Practice Pub Date : 2023-01-01 DOI:10.1155/2023/1269504

Fang Wu, Chao Wei, Shicun Zhang, Shanshan Jia, Jidong Zhang

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引用次数: 0

Abstract

Background: There is controversy regarding whether patients with single hepatocellular carcinoma (HCC) should be offered radiofrequency ablation (RFA) as a first-line treatment option. Thus, this study compared overall survival after surgical resection (SR) and RFA for single HCC.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used for this retrospective study. The study included 30- to 84-year-old patients diagnosed with HCC from 2000 to 2018. Selection bias was reduced via propensity score matching (PSM). The study compared the overall survival (OS) and cancer-specific survival (CSS) of patients with single HCC who were treated with SR and RFA.

Results: Before and after PSM, the median OS and median CSS were significantly longer in the SR group than in the RFA group (p < 0.05). In the subgroup analysis, the median OS and median CSS for male and female patients with male and female patients with tumor sizes <3, 3-5, and>5 cm, age at diagnosis between 60 and 84 years, and grades I-IV tumors were longer than in the SR group than in the RFA group (p < 0.05). Similar results were reported for patients who received chemotherapy (p < 0.05). Univariate and multivariate analyses revealed that compared with RFA, SR was an independent favorable factor for OS and CSS (p < 0.05) before and after PSM.

Conclusion: Patients with SR who had a single HCC showed higher OS and CSS compared with patients who received RFA. Hence, SR should be used as a first-line treatment in cases of single HCC.

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手术切除与射频消融治疗单肝细胞癌的疗效:一项基于seer的研究。

背景:单肝细胞癌(HCC)患者是否应给予射频消融(RFA)作为一线治疗选择存在争议。因此，本研究比较了单个HCC手术切除后的总生存率(SR)和RFA。方法:采用监测、流行病学和最终结果(SEER)数据库进行回顾性研究。该研究包括2000年至2018年诊断为HCC的30至84岁患者。通过倾向得分匹配(PSM)减少选择偏倚。该研究比较了接受SR和RFA治疗的单发HCC患者的总生存期(OS)和癌症特异性生存期(CSS)。结果:PSM前后，SR组的中位OS和中位CSS均明显长于RFA组(p < 0.05)。在亚组分析中，肿瘤大小为5 cm、诊断年龄为60 ~ 84岁、肿瘤分级为I-IV级的男性和女性患者中位OS和中位CSS均长于SR组(p < 0.05)。接受化疗的患者也有类似的结果(p < 0.05)。单因素和多因素分析显示，与RFA相比，SR是PSM前后OS和CSS的独立有利因素(p < 0.05)。结论:与接受RFA的患者相比，单发HCC的SR患者OS和CSS更高。因此，在单发HCC病例中，SR应作为一线治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.