Myofilament-associated proteins with intrinsic disorder (MAPIDs) and their resolution by computational modeling.

IF 7.2 2区 生物学 Q1 BIOPHYSICS
Bin Sun, Peter M Kekenes-Huskey
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引用次数: 0

Abstract

The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to generate force and adapt to demands on cardiac output. Intriguingly, the majority of these proteins have significant intrinsic disorder that contributes to their functions, yet the biophysics of these intrinsically disordered regions (IDRs) have been characterized in limited detail. In this review, we first enumerate these myofilament-associated proteins with intrinsic disorder (MAPIDs) and recent biophysical studies to characterize their IDRs. We secondly summarize the biophysics governing IDR properties and the state-of-the-art in computational tools toward MAPID identification and characterization of their conformation ensembles. We conclude with an overview of future computational approaches toward broadening the understanding of intrinsic disorder in the cardiac sarcomere.

具有内在紊乱的肌丝相关蛋白(MAPIDs)及其计算模型解析。
心肌肌节是心脏中使肌肉细胞收缩的细胞结构。数十种蛋白质属于心肌肌节,它们协同工作以产生力量并适应对心脏输出量的要求。耐人寻味的是,这些蛋白质中的大多数都具有显著的内在无序性,从而影响了它们的功能,然而人们对这些内在无序区(IDR)的生物物理学特性却知之甚少。在这篇综述中,我们首先列举了这些具有内在无序性的肌丝相关蛋白(MAPIDs)以及最近对其内在无序区进行表征的生物物理研究。其次,我们总结了支配 IDR 特性的生物物理学以及用于识别 MAPID 和表征其构象组合的最新计算工具。最后,我们将概述未来的计算方法,以拓宽对心肌内在无序性的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Quarterly Reviews of Biophysics
Quarterly Reviews of Biophysics 生物-生物物理
CiteScore
12.90
自引率
1.60%
发文量
16
期刊介绍: Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.
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