Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms

IF 2.4 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research Pub Date : 2022-08-15 DOI:10.1002/mpr.1931

Petra J. W. Pouwels, Chris Vriend, Feng Liu, Niels T. de Joode, Maria C. G. Otaduy, Bruno Pastorello, Frances C. Robertson, Ganesan Venkatasubramanian, Jonathan Ipser, Seonjoo Lee, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Christine Lochner, Euripedes C. Miguel, Janardhanan C. Narayanaswamy, Rashmi Rao, Y. C. Janardhan Reddy, Roseli G. Shavitt, Karthik Sheshachala, Dan J. Stein, Anton J. L. M. van Balkom, Melanie Wall, Helen Blair Simpson, Odile A. van den Heuvel

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引用次数: 0

Abstract

Objectives

We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations.

Methods

We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans.

Results

Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites.

Conclusions

Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.

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强迫症的全球多中心多模态磁共振成像研究:健康志愿者和幻影协议的协调和监测

我们描述了一项正在进行的全球强迫症研究的统一MRI采集和质量评估，目的是将神经精神病学研究中具有代表性的、强有力的神经影像学发现转化为全球人群。方法我们报告了140名健康参与者(每个部位28人)的t1加权结构MRI、静息状态功能MRI和多壳弥散加权成像，两名旅行对照组和常规幻像扫描。结果人体图像质量指标(Human image quality measures, IQMs)和结果指标在站点内的变化小于站点间的变化。结果测量比iqm变量更小，特别是对于旅行控制组。幻影iqm在几何形状、信噪比和平均扩散率方面是稳定的，而fMRI的波动在不同的位点之间变化更大。结论:即使对于先验的协调数据采集方案，iqm的差异仍然存在，但预处理后它们对结果测量的影响较小。连续监视每个站点的iqm对于检测潜在的工件和异常值是有价值的。在每个地点纳入病例和健康参与者仍然是强制性的。

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来源期刊

International Journal of Methods in Psychiatric Research 医学-精神病学

CiteScore

5.20

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Methods in Psychiatric Research (MPR) publishes high-standard original research of a technical, methodological, experimental and clinical nature, contributing to the theory, methodology, practice and evaluation of mental and behavioural disorders. The journal targets in particular detailed methodological and design papers from major national and international multicentre studies. There is a close working relationship with the US National Institute of Mental Health, the World Health Organisation (WHO) Diagnostic Instruments Committees, as well as several other European and international organisations. MPR aims to publish rapidly articles of highest methodological quality in such areas as epidemiology, biostatistics, generics, psychopharmacology, psychology and the neurosciences. Articles informing about innovative and critical methodological, statistical and clinical issues, including nosology, can be submitted as regular papers and brief reports. Reviews are only occasionally accepted. MPR seeks to monitor, discuss, influence and improve the standards of mental health and behavioral neuroscience research by providing a platform for rapid publication of outstanding contributions. As a quarterly journal MPR is a major source of information and ideas and is an important medium for students, clinicians and researchers in psychiatry, clinical psychology, epidemiology and the allied disciplines in the mental health field.