A COVID-19 mystery: multisystem inflammatory syndrome in adults (MIS-A) associated with splenic rupture.

IF 1.5 4区 医学 Q4 MICROBIOLOGY
New Microbiologica Pub Date : 2023-02-01
Isil Isel, Istemi Serin, Beyza Kal Kolik, Hasan Goze, Tahir Alper Cinli, Gulben Erdem Huq, Mahmut Emin Cicek, Sermin Altindal, Osman Yokus
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引用次数: 0

Abstract

Severe inflammation and one or more extrapulmonary organ dysfunctions have been observed in those who had recently developed COVID-19, except for a macrophage activation syndrome-like picture. A 50-year-old female patient was admitted to the emergency department with fever and a history of COVID-19 infection. More than one area of hemophagocytosis was found in the bone marrow aspiration. The HLH-2004 protocol was started with neurological involvement and she underwent splenectomy due to massive intra-abdominal bleeding secondary to splenic laceration on the 3rd day. Multiple microthrombosis and infarcts were observed in the splenectomy specimen. At the 4th week of the treatment, she was discharged with oral agents. Splenic microthrombosis and splenic rupture due to "multisystem inflammatory syndrome in adults" are the most important findings of this report.

COVID-19之谜:成人多系统炎症综合征(MIS-A)与脾破裂相关。
在最近发生COVID-19的患者中,除了巨噬细胞激活综合征样图像外,还观察到严重炎症和一种或多种肺外器官功能障碍。50岁女性患者因发热和COVID-19感染史入院急诊科。骨髓抽吸出现多处噬血细胞现象。HLH-2004方案从神经系统受损伤开始,她于第3天因脾裂伤继发大量腹腔内出血而行脾切除术。脾切除标本可见多发微血栓及梗死。治疗第4周,患者口服药物出院。“成人多系统炎症综合征”引起的脾微血栓形成和脾破裂是本报告最重要的发现。
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来源期刊
New Microbiologica
New Microbiologica 生物-微生物学
CiteScore
2.20
自引率
5.60%
发文量
40
审稿时长
6-12 weeks
期刊介绍: The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.
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