Pooja Kamlesh Gajaria, Santosh Menon, Ganesh Bakshi, Gagan Prakash, Amit Joshi, Vedang Murthy, Sangeeta B Desai
{"title":"Plasmacytoid urothelial carcinoma - A clinicopathological case series of an aggressive variant of urothelial cancer.","authors":"Pooja Kamlesh Gajaria, Santosh Menon, Ganesh Bakshi, Gagan Prakash, Amit Joshi, Vedang Murthy, Sangeeta B Desai","doi":"10.4103/ijc.IJC_617_20","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Many new morphological variants of urothelial carcinoma of urinary bladder have been described in the literature, plasmacytoid/signet ring cell/diffuse variant being one of the rare amongst these. Till date, no case series has been reported from India, describing this variant.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed the clinicopathological data of 14 patients diagnosed at our center with plasmacytoid urothelial carcinoma.</p><p><strong>Results: </strong>Seven cases (50%) were pure forms while the remaining 50% of cases had a concurrent conventional urothelial carcinoma component. Immunohistochemistry was performed to rule out other mimickers of this variant. Treatment-related data were available for seven patients, while follow-up was available for nine cases.</p><p><strong>Conclusion: </strong>Overall, plasmacytoid variant of urothelial carcinoma is considered to be an aggressive tumor with poor prognosis.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/ijc.IJC_617_20","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/10 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Many new morphological variants of urothelial carcinoma of urinary bladder have been described in the literature, plasmacytoid/signet ring cell/diffuse variant being one of the rare amongst these. Till date, no case series has been reported from India, describing this variant.
Materials and methods: We retrospectively analyzed the clinicopathological data of 14 patients diagnosed at our center with plasmacytoid urothelial carcinoma.
Results: Seven cases (50%) were pure forms while the remaining 50% of cases had a concurrent conventional urothelial carcinoma component. Immunohistochemistry was performed to rule out other mimickers of this variant. Treatment-related data were available for seven patients, while follow-up was available for nine cases.
Conclusion: Overall, plasmacytoid variant of urothelial carcinoma is considered to be an aggressive tumor with poor prognosis.
期刊介绍：
Indian Journal of Cancer (ISSN 0019-509X), the show window of the progress of ontological sciences in India, was established in 1963. Indian Journal of Cancer is the first and only periodical serving the needs of all the specialties of oncology in India.
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