Utilization of ultrasound in photoimmunotherapy for head and neck cancer: a case report.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Ultrasound Pub Date : 2025-03-01 Epub Date: 2023-02-18 DOI:10.1007/s40477-023-00774-8

Toshihiro Kishikawa, Hoshino Terada, Michi Sawabe, Shintaro Beppu, Daisuke Nishikawa, Hidenori Suzuki, Nobuhiro Hanai

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引用次数: 0

Abstract

Background: Photoimmunotherapy (PIT) is a new cancer treatment based on a different mechanism from conventional treatments that combines the administration of a photoabsorber and laser illumination. PIT has two characteristics: a high selectivity of target cells and the possibility of effects beyond the illuminated area. It is thus a potentially effective treatment for a wide variety of cancers.

Case presentation: We herein report a patient with oropharyngeal squamous cell carcinoma with superficial cervical lymph node recurrence. Intraoperative ultrasound confirmed the localization of the lesion and major vessels near the tumor. We punctured the tumor with catheters of laser illumination under ultrasound guidance. Laser illumination was able to be performed safely without causing serious adverse events, and the effect on the illuminated site was fully exhibited.

Conclusions: Ultrasound allows for the intraoperative monitoring of each localized area and the puncture status easily in real-time. Accurate utilization of ultrasound is extremely important in PIT.

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头颈部癌症光免疫疗法中超声波的应用：病例报告。

背景：光免疫疗法（PIT）是一种基于不同于传统治疗机制的新型癌症治疗方法，它将光吸收剂的施用与激光照射相结合。光免疫疗法有两个特点：对靶细胞的高度选择性和在照射区域外产生效应的可能性。因此，它是一种治疗多种癌症的潜在有效方法：我们在此报告了一名口咽鳞癌伴浅表颈淋巴结复发的患者。术中超声确认了病灶的位置和肿瘤附近的主要血管。我们在超声引导下用激光照射导管穿刺肿瘤。激光照射能够安全进行，不会引起严重的不良反应，照射部位的效果也得到了充分展示：结论：超声可在术中轻松实时地监测每个局部区域和穿刺状态。准确利用超声波在 PIT 中极为重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ultrasound RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.10

自引率

15.00%

发文量

133

期刊介绍： The Journal of Ultrasound is the official journal of the Italian Society for Ultrasound in Medicine and Biology (SIUMB). The journal publishes original contributions (research and review articles, case reports, technical reports and letters to the editor) on significant advances in clinical diagnostic, interventional and therapeutic applications, clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and in cross-sectional diagnostic imaging. The official language of Journal of Ultrasound is English.