Cognitive Effects Following Offline High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) in Healthy Populations: A Systematic Review and Meta-Analysis.

IF 5.4 2区心理学 Q1 NEUROSCIENCES

Neuropsychology Review Pub Date : 2024-03-01 Epub Date: 2023-03-01 DOI:10.1007/s11065-023-09580-9

Mei Xu, Stevan Nikolin, Nisal Samaratunga, Esther Jia Hui Chow, Colleen K Loo, Donel M Martin

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Abstract

High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a commonly used form of rTMS to treat neuropsychiatric disorders. Emerging evidence suggests that 'offline' HF-rTMS may have cognitive enhancing effects, although the magnitude and moderators of these effects remain unclear. We conducted a systematic review and meta-analysis to clarify the cognitive effects of offline HF-rTMS in healthy individuals. A literature search for randomised controlled trials with cognitive outcomes for pre and post offline HF-rTMS was performed across five databases up until March 2022. This study was registered on the PROSPERO international prospective protocol for systematic reviews (PROSPERO 2020 CRD 42,020,191,269). The Risk of Bias 2 tool was used to assess the risk of bias in randomised trials. Separate analyses examined the cognitive effects of excitatory and inhibitory forms of offline HF-rTMS on accuracy and reaction times across six cognitive domains. Fifty-three studies (N = 1507) met inclusion criteria. Excitatory offline HF-rTMS showed significant small sized effects for improving accuracy (k = 46, g = 0.12) and reaction time (k = 44, g = -0.13) across all cognitive domains collapsed. Excitatory offline HF-rTMS demonstrated a relatively greater effect for executive functioning in accuracy (k = 24, g = 0.14). Reaction times were also improved for the executive function (k = 21, g = -0.11) and motor (k = 3, g = -0.22) domains following excitatory offline HF-rTMS. The current review was restricted to healthy individuals and future research is required to examine cognitive enhancement from offline HF-rTMS in clinical cohorts.

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健康人群接受离线高频重复经颅磁刺激（HF-rTMS）后的认知效应：系统回顾与元分析》。

高频重复经颅磁刺激（HF-rTMS）是治疗神经精神疾病的一种常用经颅磁刺激形式。新的证据表明，"离线 "高频经颅磁刺激可能具有增强认知能力的作用，但这些作用的程度和调节因素仍不清楚。我们进行了一项系统回顾和荟萃分析，以明确离线高频经颅磁刺激对健康人认知的影响。截至 2022 年 3 月，我们在五个数据库中搜索了离线高频经颅磁刺激前后认知结果的随机对照试验文献。该研究已在 PROSPERO 国际前瞻性系统综述协议（PROSPERO 2020 CRD 42,020,191,269）上注册。偏倚风险2工具用于评估随机试验的偏倚风险。分别分析了离线高频经颅磁刺激的兴奋型和抑制型对六个认知领域的准确性和反应时间的认知影响。53项研究（N = 1507）符合纳入标准。兴奋型离线高频经颅磁刺激在提高所有认知领域的准确性（k = 46，g = 0.12）和反应时间（k = 44，g = -0.13）方面显示出显著的小规模效应。兴奋性离线高频经颅磁刺激对执行功能准确性的影响相对较大（k = 24，g = 0.14）。兴奋性离线高频经颅磁刺激后，执行功能（k = 21，g = -0.11）和运动（k = 3，g = -0.22）领域的反应时间也有所改善。目前的综述仅限于健康人，未来的研究需要在临床人群中检验离线高频经颅磁刺激对认知能力的增强作用。

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来源期刊

Neuropsychology Review 医学-神经科学

CiteScore

11.00

自引率

1.70%

发文量

期刊介绍： Neuropsychology Review is a quarterly, refereed publication devoted to integrative review papers on substantive content areas in neuropsychology, with particular focus on populations with endogenous or acquired conditions affecting brain and function and on translational research providing a mechanistic understanding of clinical problems. Publication of new data is not the purview of the journal. Articles are written by international specialists in the field, discussing such complex issues as distinctive functional features of central nervous system disease and injury; challenges in early diagnosis; the impact of genes and environment on function; risk factors for functional impairment; treatment efficacy of neuropsychological rehabilitation; the role of neuroimaging, neuroelectrophysiology, and other neurometric modalities in explicating function; clinical trial design; neuropsychological function and its substrates characteristic of normal development and aging; and neuropsychological dysfunction and its substrates in neurological, psychiatric, and medical conditions. The journal''s broad perspective is supported by an outstanding, multidisciplinary editorial review board guided by the aim to provide students and professionals, clinicians and researchers with scholarly articles that critically and objectively summarize and synthesize the strengths and weaknesses in the literature and propose novel hypotheses, methods of analysis, and links to other fields.