Dysregulated Diurnal Cortisol Pattern and Heightened Night-Time Cortisol in Individuals with Bipolar Disorder.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2022-01-01 DOI:10.1159/000517343

Dahlia Mukherjee, J Dylan Weissenkampen, Emily Wasserman, Venkatesh Basappa Krishnamurthy, Caitlin E Millett, Stephen Conway, Erika F H Saunders

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引用次数: 3

Abstract

Introduction: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation may contribute to the symptom burden in bipolar disorder (BD). Further characterization of cortisol secretion is needed to improve understanding of the connection between mood, sleep, and the HPA axis. Here, we observe diurnal cortisol patterns in individuals with BD and healthy controls (HCs) to determine time points where differences may occur.

Methods: Salivary cortisol was measured at 6 time points (wake, 15, 30, and 45 min after wake, between 2:00 and 4:00 p.m. and 10:00 p.m.) for 3 consecutive days in individuals with symptomatic BD (N = 27) and HC participants (N = 31). A general linear model with correlated errors was utilized to determine if salivary cortisol changed differently throughout the day between the 2 study groups.

Results: A significant interaction (F = 2.74, df = 5, and p = 0.02) was observed between the time of day and the study group (BD vs. HC) when modeling salivary cortisol over time, indicating that salivary cortisol levels throughout the day significantly differed between the study groups. Specifically, salivary cortisol in BD was elevated compared to HCs at the 10:00 p.m. time point (p = 0.01).

Conclusion: Significantly higher levels of cortisol in participants with BD in the night-time suggest that the attenuation of cortisol observed in healthy individuals may be impaired in those with BD. Reregulation of cortisol levels may be a target of further study and treatment intervention for individuals with BD.

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双相情感障碍患者昼夜皮质醇模式失调和夜间皮质醇升高。

下丘脑-垂体-肾上腺(HPA)轴失调可能导致双相情感障碍(BD)的症状负担。为了更好地理解情绪、睡眠和下丘脑轴之间的联系，需要进一步表征皮质醇分泌。在这里，我们观察了双相障碍患者和健康对照(hc)的皮质醇昼夜模式，以确定可能发生差异的时间点。方法:连续3天，在6个时间点(醒来后15、30和45分钟，下午2点至4点和晚上10点)测量有症状的BD患者(N = 27)和HC参与者(N = 31)的唾液皮质醇。采用具有相关误差的一般线性模型来确定两个研究组之间的唾液皮质醇全天变化是否不同。结果:在模拟唾液皮质醇随时间变化时，观察到一天中的时间与研究组(BD vs. HC)之间存在显著的相互作用(F = 2.74, df = 5, p = 0.02)，表明全天的唾液皮质醇水平在研究组之间存在显著差异。具体而言，在晚上10:00时，BD患者的唾液皮质醇与hc患者相比升高(p = 0.01)。结论:夜间BD患者皮质醇水平明显升高，提示健康个体皮质醇的衰减可能在BD患者中受损，皮质醇水平的再调节可能是BD患者进一步研究和治疗干预的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.