Effectiveness of quantitative bone SPECT/CT for bone metastasis diagnosis.

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2022-09-01 DOI:10.1967/s002449912513

Takashi Ikeda, Kazuhiro Kitajima, Tatsuya Tsuchitani, Yoshiyuki Takahashi, Yasuhiko Hama, Noriko Kotura

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引用次数: 4

Abstract

Objective: This study was conducted to investigate the utility of standardized uptake value (SUV) derived from bone single photon emission tomography/computed tomography (SPECT/CT) for diagnosing bone metastasis.

Subjects and methods: One hundred forty-seven patients with malignant cancer (breast or prostate cancer), joint disorders, primary skeletal disease, or cartilaginous bone neoplasms who underwent skeletal quantitative SPECT/CT were retrospectively investigated. Acquired data were classified as normal fourth lumbar vertebra, skeletal degenerative changes, or bone metastasis. Receiver operating characteristic (ROC) curves were used to determine the optimum cut-off value for SUVmax to distinguish among these diagnoses.

Results: Mean SUVmax values for the normal L4 bone (n=101), skeletal degenerative changes (n=47) and bone metastasis (n=64) groups were 4.47±1.66 (range 1.01-11.25), 6.99±2.58 (2.21-14.6), and 25.4±15.7 (3.88-98.87), respectively. Compared to the other two groups, SUVmax for the bone metastasis group was significantly higher (P<0.001). In the normal bone group, sensitivity, specificity and accuracy for discriminating bone metastasis were 96.3%, 95.1%, and 95.7% respectively, with a best SUVmax cut-off value of 7.40. For the skeletal degenerative changes group sensitivity, specificity and accuracy were 87.5%, 93.6%, and 90.4% respectively, with a best SUVmax cut-off value of 11.26.

Conclusion: Quantitative bone SPECT/CT may be useful for bone metastasis diagnosis.

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定量骨SPECT/CT诊断骨转移的有效性。

目的:探讨骨单光子发射断层扫描/计算机断层扫描(SPECT/CT)获得的标准化摄取值(SUV)在骨转移诊断中的应用价值。对象和方法:回顾性研究147例恶性肿瘤(乳腺癌或前列腺癌)、关节疾病、原发性骨骼疾病或软骨骨肿瘤患者的骨骼定量SPECT/CT。获得的数据分为正常第四腰椎、骨骼退行性改变或骨转移。采用受试者工作特征(ROC)曲线确定SUVmax的最佳临界值，以区分这些诊断。结果:正常L4骨组(n=101)、骨骼退行性变组(n=47)、骨转移组(n=64)的平均SUVmax值分别为4.47±1.66(1.01 ~ 11.25)、6.99±2.58(2.21 ~ 14.6)、25.4±15.7(3.88 ~ 98.87)。与其他两组相比，骨转移组的SUVmax明显高于其他两组(p结论:定量骨SPECT/CT可能有助于骨转移的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.