The multiple roles of dopamine receptor activation in the modulation of gastrointestinal motility and mucosal function

IF 3.2 4区 医学 Q2 NEUROSCIENCES
Rosa Serio , Maria Grazia Zizzo
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引用次数: 0

Abstract

Dopamine (DA) is a catecholamine regulatory molecule with potential role in physiology and physiopathology of the intestinal tract. Various cellular sources of DA have been indicated as enteric neurons, immune cells, intestinal flora and gastrointestinal epithelium. Moreover, DA is produced by nutritional tyrosine. All the five DA receptors, actually described, are present throughout the gut. Current knowledge of DA in this area is reviewed, focusing on gastrointestinal function in health and during inflammation. Research on animal models and humans are reported. A major obstacle to understanding the physiologic and/or pharmacological roles of enteric DA is represented by the multiplicity of receptors involved in the responses together with many signalling pathways related to each receptor subtype. It is mandatory to map precisely the distributions of DA receptors, to determine the relevance of a receptor in a specific location in order to explore novel therapies directed to dopaminergic targets that may be useful in the control of intestinal inflammation.

Abstract Image

多巴胺受体激活在胃肠运动和粘膜功能调节中的多重作用
多巴胺(DA)是一种儿茶酚胺调节分子,在肠道生理和病理中具有潜在的作用。DA的各种细胞来源已被指出为肠道神经元、免疫细胞、肠道菌群和胃肠道上皮。此外,DA是由营养酪氨酸产生的。事实上,所有五种DA受体都存在于整个肠道中。综述了DA在这一领域的最新知识,重点介绍了健康和炎症过程中的胃肠功能。报道了对动物模型和人类的研究。理解肠道DA的生理和/或药理学作用的一个主要障碍是参与反应的多种受体以及与每种受体亚型相关的许多信号通路。必须精确绘制DA受体的分布图,以确定受体在特定位置的相关性,从而探索针对多巴胺能靶点的新疗法,这些疗法可能有助于控制肠道炎症。
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来源期刊
CiteScore
5.80
自引率
7.40%
发文量
83
审稿时长
66 days
期刊介绍: This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.
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