Hormonal contraceptives and the brain: A systematic review on 60 years of neuroimaging, EEG, and biochemical studies in humans and animals

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI:10.1016/j.yfrne.2022.101051

Joan Y. Song , Caroline Delbourgo Patton , Renee Friedman , Lakshmi S. Mahajan , Rachel Nordlicht , Rahman Sayed , Michael L. Lipton

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引用次数: 3

Abstract

Hormonal contraception has been widely prescribed for decades. Although safety and efficacy are well-established, much uncertainty remains regarding brain effects of hormonal contraception. We systematically review human and animal studies on the brain effects of hormonal contraception which employed neuroimaging techniques such as MRI, PET and EEG, as well as animal studies which reported on neurotransmitter and other brain biochemical effects. We screened 1001 articles and ultimately extracted data from 70, comprising 51 human and 19 animal studies. Of note, there were no animal studies which employed structural or functional MRI, MRS or PET. In summary, our review shows hormonal contraceptive associations with changes in the brain have been documented. Many questions remain and more studies are needed to describe the effects of hormonal contraception on the brain.

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激素避孕药与大脑:对60年来人类和动物神经成像、脑电图和生化研究的系统回顾

激素避孕已经被广泛使用了几十年。尽管安全性和有效性已得到证实，但激素避孕对大脑的影响仍存在许多不确定性。我们系统地回顾了使用MRI、PET和EEG等神经成像技术对激素避孕对大脑影响的人类和动物研究，以及报道神经递质和其他大脑生化影响的动物研究。我们筛选了1001篇文章，最终从70篇文章中提取了数据，其中包括51项人类研究和19项动物研究。值得注意的是，没有采用结构或功能MRI、MRS或PET的动物研究。总之，我们的综述表明，激素避孕与大脑变化的关系已经被记录在案。许多问题仍然存在，需要更多的研究来描述激素避孕对大脑的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.