Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice.

IF 3.9 4区医学 Q2 NEUROSCIENCES

ASN NEURO Pub Date : 2023-01-01 DOI:10.1177/17590914231152099

Fei Zeng, Karsten Parker, Yanqiang Zhan, Matthew Miller, Meng-Yang Zhu

引用次数: 0

Abstract

Summary statement: The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.

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帕金森病模型小鼠中DNA损伤相关生物标志物的上调

摘要:本研究检测了VMAT2 Lo PD模型小鼠DNA损伤标志物的表达。结果表明，这些DNA损伤标志物在18和23月龄模型小鼠的大脑区域显著增加，表明氧化应激诱导的DNA损伤是该模型小鼠的重要病理特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ASN NEURO NEUROSCIENCES-

CiteScore

7.70

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.