A review of COVID vaccines: success against a moving target.

IF 6.7 2区医学 Q1 Medicine

British medical bulletin Pub Date : 2022-12-12 DOI:10.1093/bmb/ldac025

S H Chong, L A Burn, T K M Cheng, I S Warr, J C Kenyon

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引用次数: 3

Abstract

Background: Multiple vaccine platforms against COVID-19 have been developed and found safe and efficacious at a record speed. Although most are effective, they vary in their ease of production and distribution, their potential speed of modification against new variants, and their durability of protection and safety in certain target groups.

Sources of data: Our discussion is based on published reports of clinical trials and analyses from national and global health agencies.

Areas of agreement: The production of neutralizing antibodies against the viral spike protein is protective, and all vaccines for which published data exist have been found to be effective against severe disease caused by the viral strain they target.

Areas of controversy: The degree to which vaccines protect against emerging variants, moderate disease and asymptomatic infection remains somewhat unclear.

Growing points: Knowledge of the duration of protection and its decay is increasing, and discussions of booster frequency and target strains are ongoing.

Areas timely for developing research: The global effort to combat transmission and disease continues to rely upon intense epidemiological surveillance, whilst real-world data and clinical trials shape vaccination schedules and formulae.

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COVID - 19疫苗综述:成功应对移动目标

背景:针对COVID-19的多种疫苗平台已被开发出来，并以创纪录的速度被发现安全有效。虽然大多数都是有效的，但它们在生产和分发的难易程度、针对新变种的潜在修改速度以及它们在某些目标群体中的保护持久性和安全性方面各不相同。数据来源:我们的讨论基于已发表的临床试验报告以及国家和全球卫生机构的分析。达成一致的领域:产生针对病毒刺突蛋白的中和抗体具有保护作用，所有已发表数据的疫苗都被发现对其所针对的病毒株引起的严重疾病有效。争议领域:疫苗在多大程度上预防新出现的变种、中度疾病和无症状感染仍不清楚。生长点:关于保护持续时间及其衰减的知识正在增加，关于增强频率和目标应变的讨论正在进行中。及时开展研究的领域:全球防治传播和疾病的努力继续依赖于密切的流行病学监测，而实际数据和临床试验则决定了疫苗接种时间表和配方。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British medical bulletin 医学-医学：内科

CiteScore

13.10

自引率

1.50%

发文量

审稿时长

>12 weeks

期刊介绍： British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries. Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.