Strain wars 5: Gibbs energies of binding of BA.1 through BA.4 variants of SARS-CoV-2

IF 3 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Microbial Risk Analysis Pub Date : 2022-12-01 DOI:10.1016/j.mran.2022.100231

Marko Popovic

引用次数: 15

Abstract

This paper reports, for the first time, standard Gibbs energies of binding of the BA.1, BA.2, BA.3, BA.2.13, BA.2.12.1 and BA.4 Omicron variants of SARS-CoV-2, to the Human ACE2 receptor. Variants BA.1 through BA.3 exhibit a trend of decreasing standard Gibbs energy of binding and hence increased infectivity. The BA.4 variant exhibits a less negative standard Gibbs energy of binding, but also more efficient evasion of the immune response. Therefore, it was concluded that all the analyzed strains evolve in accordance with expectations of the theory of evolution, albeit using different strategies.

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菌株之战5:SARS-CoV-2的BA.1到BA.4变体的吉布斯结合能

本文首次报道了SARS-CoV-2的BA.1、BA.2、BA.3、BA.2.13、BA.2.12.1和BA.4组克隆变体与人ACE2受体结合的标准吉布斯能。BA.1 ~ BA.3变异体表现出降低标准吉布斯结合能的趋势，从而增加了传染性。BA.4变体表现出较低的负标准吉布斯结合能，但也更有效地逃避免疫反应。因此，我们得出的结论是，所有被分析的菌株都按照进化论的预期进化，尽管使用了不同的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial Risk Analysis Medicine-Microbiology (medical)

CiteScore

5.70

自引率

7.10%

发文量

审稿时长

52 days

期刊介绍： The journal Microbial Risk Analysis accepts articles dealing with the study of risk analysis applied to microbial hazards. Manuscripts should at least cover any of the components of risk assessment (risk characterization, exposure assessment, etc.), risk management and/or risk communication in any microbiology field (clinical, environmental, food, veterinary, etc.). This journal also accepts article dealing with predictive microbiology, quantitative microbial ecology, mathematical modeling, risk studies applied to microbial ecology, quantitative microbiology for epidemiological studies, statistical methods applied to microbiology, and laws and regulatory policies aimed at lessening the risk of microbial hazards. Work focusing on risk studies of viruses, parasites, microbial toxins, antimicrobial resistant organisms, genetically modified organisms (GMOs), and recombinant DNA products are also acceptable.