Xiaomei Liu Ph.D. , Zhuoya Ma M.Sc. , Xinyi Zhu Ph.D. , Zhiwei Zheng Ph.D. , Jing Li Ph.D. , Jiangning Fu M.Sc. , Qi Shao M.Sc. , Xiaoyan Han M.Med , Xiaoning Wang Ph.D. , Zhihui Wang Ph.D. , Zhaoxue Yin Ph.D. , Chengxuan Qiu Ph.D. , Juan Li Ph.D.
{"title":"Cognitive Benefit of a Multidomain Intervention for Older Adults at Risk of Cognitive Decline: A Cluster-Randomized Controlled Trial","authors":"Xiaomei Liu Ph.D. , Zhuoya Ma M.Sc. , Xinyi Zhu Ph.D. , Zhiwei Zheng Ph.D. , Jing Li Ph.D. , Jiangning Fu M.Sc. , Qi Shao M.Sc. , Xiaoyan Han M.Med , Xiaoning Wang Ph.D. , Zhihui Wang Ph.D. , Zhaoxue Yin Ph.D. , Chengxuan Qiu Ph.D. , Juan Li Ph.D.","doi":"10.1016/j.jagp.2022.10.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>We sought to assess cognitive benefits of a community-based multidomain intervention for improving cognition among older adults at risk of cognitive decline (COMBAT).</p></div><div><h3>Design</h3><p>A two-armed cluster-randomized controlled trial.</p></div><div><h3>Setting and Participants</h3><p>Community-dwelling older adults aged 60 years or older and were at risk of cognitive decline (n = 209).</p></div><div><h3>Intervention</h3><p>In this 9-month intervention study, 10 community hospitals in Beijing, China, were randomized (1:1) to receive either a multidomain intervention of meditation, cognitive training, exercise, and nutrition counseling or usual care. The intervention was delivered with weekly 1-hour group training sessions and weekly home homework.</p></div><div><h3>Measurements</h3><p>Primary outcome was change in cognition as measured by a composite Z score of seven cognitive tests. Secondary outcomes included subjective cognitive abilities, positive and negative affective experiences, physical activity, and dietary habits. Assessments were administered at baseline, end of the intervention, and 1 year after completing the intervention (1-year follow-up).</p></div><div><h3>Results</h3><p>Immediately after the intervention, the intervention group showed significant enhancement in cognitive performance (p = 0.026). The between-group difference in the Z score of change of cognition was 0.20 (95% CI: 0.053, 0.35), with a Hedges’ <em>g</em> of 0.40 (95% CI: 0.29, 0.50). However, this cognitive benefit was not significant at 1-year follow-up.</p></div><div><h3>Conclusion</h3><p>This multidomain intervention was effective to improve cognition for at-risk individuals. Long-term effects on cognitive function and individual differences in response to the intervention deserve further investigation.</p></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Geriatric Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1064748122005462","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Objective
We sought to assess cognitive benefits of a community-based multidomain intervention for improving cognition among older adults at risk of cognitive decline (COMBAT).
Design
A two-armed cluster-randomized controlled trial.
Setting and Participants
Community-dwelling older adults aged 60 years or older and were at risk of cognitive decline (n = 209).
Intervention
In this 9-month intervention study, 10 community hospitals in Beijing, China, were randomized (1:1) to receive either a multidomain intervention of meditation, cognitive training, exercise, and nutrition counseling or usual care. The intervention was delivered with weekly 1-hour group training sessions and weekly home homework.
Measurements
Primary outcome was change in cognition as measured by a composite Z score of seven cognitive tests. Secondary outcomes included subjective cognitive abilities, positive and negative affective experiences, physical activity, and dietary habits. Assessments were administered at baseline, end of the intervention, and 1 year after completing the intervention (1-year follow-up).
Results
Immediately after the intervention, the intervention group showed significant enhancement in cognitive performance (p = 0.026). The between-group difference in the Z score of change of cognition was 0.20 (95% CI: 0.053, 0.35), with a Hedges’ g of 0.40 (95% CI: 0.29, 0.50). However, this cognitive benefit was not significant at 1-year follow-up.
Conclusion
This multidomain intervention was effective to improve cognition for at-risk individuals. Long-term effects on cognitive function and individual differences in response to the intervention deserve further investigation.
期刊介绍：
The American Journal of Geriatric Psychiatry is the leading source of information in the rapidly evolving field of geriatric psychiatry. This esteemed journal features peer-reviewed articles covering topics such as the diagnosis and classification of psychiatric disorders in older adults, epidemiological and biological correlates of mental health in the elderly, and psychopharmacology and other somatic treatments. Published twelve times a year, the journal serves as an authoritative resource for professionals in the field.
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