Diagnostic hysteroscopy with endometrial fundal incision may improve reproductive outcomes in oocyte recipients after implantation failure.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Nikolaos Peitsidis, Ioannis Tsakiridis, Robert Najdecki, Georgios Michos, Foteini Chouliara, Evi Timotheou, Tatiana Chartomatsidou, Apostolos Athanasiadis, Evangelos Papanikolaou
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Abstract

Objective: This study aimed to investigate whether hysteroscopy plus endometrial fundal incision (EFI) with endoscopic scissors can improve reproductive outcomes in oocyte recipients who have failed in their first egg donation cycle.

Methods: This was a prospective study (2014-2022) conducted in Assisting Nature Centre Reproduction and Genetics, Thessaloniki Greece, IVF Unit. The study population consisted of oocyte recipients with implantation failure in their first embryo transfer (ET) with donor eggs. All the recipients underwent routine evaluation during their early follicular phase, 1-3 months before the start of a new cycle with donor oocytes and were eligible to undergo EFI.

Results: During the study period, 218 egg recipients underwent egg donation; 126 out of 218 oocyte recipients (57.8%) did not achieve a live birth at the 1st ET. 109 of them had surplus embryos cryopreserved and underwent a second ET; 50 women consented for EFI. Both groups were similar in terms of age, years of infertility, duration of estrogen replacement protocol and number of transferred blastocysts (p>0.05). In the EFI group, 60% had normal intrauterine cavity, while 40% had minor anomalies. The pregnancy test was positive in 46% (n=23/50) in the EFI group compared with 27.1% (n=16/59) in the control group (p=0.04). Moreover, live birth rates were higher in the EFI group compared to the control group (38.0% vs. 20.3%; p=0.04).

Conclusions: The findings of our study indicate that in oocyte recipients after implantation failure, diagnostic hysteroscopy plus EFI prior to subsequent ETmay increase pregnancy and live birth rates.

子宫内膜底切口诊断宫腔镜可改善卵母细胞受者着床失败后的生殖结局。
目的:本研究旨在探讨宫腔镜联合内镜剪刀子宫内膜底切口(EFI)是否可以改善第一次卵子捐赠周期失败的卵母细胞受者的生殖结局。方法:这是一项前瞻性研究(2014-2022),在希腊塞萨洛尼基辅助自然中心生殖和遗传学,试管婴儿部门进行。研究人群包括在第一次胚胎移植(ET)中植入失败的卵母细胞受体。所有受者在卵泡期早期,即供体卵母细胞新周期开始前1-3个月接受常规评估,并有资格接受EFI。结果:在研究期间,218名受赠者接受了卵子捐赠;218名卵母细胞受者中有126名(57.8%)在第一次体外受精时未实现活产,其中109名有多余的胚胎冷冻保存并进行了第二次体外受精;50名妇女同意EFI。两组患者在年龄、不孕年数、雌激素替代方案持续时间和移植囊胚数量方面差异无统计学意义(p < 0.05)。EFI组60%宫腔正常,40%有轻微异常。EFI组妊娠试验阳性率为46% (n=23/50),对照组为27.1% (n=16/59) (p=0.04)。此外,EFI组的活产率高于对照组(38.0% vs. 20.3%;p = 0.04)。结论:我们的研究结果表明,在植入失败后的卵母细胞受体中,诊断性宫腔镜加EFI在随后的etp之前可能会增加妊娠和活产率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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