Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.

IF 4.2 4区 医学 Q1 ANESTHESIOLOGY
Korean Journal of Anesthesiology Pub Date : 2023-12-01 Epub Date: 2023-02-24 DOI:10.4097/kja.23068
Ah Ran Oh, Jungchan Park, Jong-Hwan Lee, Kwangmo Yang, Joonghyun Ahn, Seung-Hwa Lee, Sangmin Maria Lee
{"title":"Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.","authors":"Ah Ran Oh, Jungchan Park, Jong-Hwan Lee, Kwangmo Yang, Joonghyun Ahn, Seung-Hwa Lee, Sangmin Maria Lee","doi":"10.4097/kja.23068","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To evaluate the association between inflammation and nutrition-based biomarkers and postoperative outcomes after non-cardiac surgery.</p><p><strong>Methods: </strong>Between January 2011 and June 2019, a total of 102,052 patients undergoing non-cardiac surgery were evaluated, with C-reactive protein (CRP), albumin, and complete blood count (CBC) measured within six months before surgery. We assessed their CRP-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and modified Glasgow Prognostic Score (mGPS). We determined the best cut-off values by using the receiver operating characteristic (ROC) curves. Patients were divided into high and low groups according to the estimated threshold, and we compared the one-year mortality.</p><p><strong>Results: </strong>The one-year mortality of the entire sample was 4.2%. ROC analysis revealed areas under the curve of 0.796, 0.743, 0.670, and 0.708 for CAR, NLR, PLR, and mGPS, respectively. According to the estimated threshold, high CAR, NLR, PLR, and mGPS were associated with increased one-year mortality (1.7% vs. 11.7%, hazard ratio [HR]: 2.38, 95% CI [2.05, 2.76], P < 0.001 for CAR; 2.2% vs. 10.3%, HR: 1.81, 95% CI [1.62, 2.03], P < 0.001 for NLR; 2.6% vs. 10.5%, HR: 1.86, 95% CI [1.73, 2.01], P < 0.001 for PLR; and 2.3% vs. 16.3%, HR: 2.37, 95% CI [2.07, 2.72], P < 0.001 for mGPS).</p><p><strong>Conclusions: </strong>Preoperative CAR, NRL, PLR, and mGPS were associated with postoperative mortality. Our findings may be helpful in predicting mortality after non-cardiac surgery.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10718634/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Anesthesiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4097/kja.23068","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Background: To evaluate the association between inflammation and nutrition-based biomarkers and postoperative outcomes after non-cardiac surgery.

Methods: Between January 2011 and June 2019, a total of 102,052 patients undergoing non-cardiac surgery were evaluated, with C-reactive protein (CRP), albumin, and complete blood count (CBC) measured within six months before surgery. We assessed their CRP-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and modified Glasgow Prognostic Score (mGPS). We determined the best cut-off values by using the receiver operating characteristic (ROC) curves. Patients were divided into high and low groups according to the estimated threshold, and we compared the one-year mortality.

Results: The one-year mortality of the entire sample was 4.2%. ROC analysis revealed areas under the curve of 0.796, 0.743, 0.670, and 0.708 for CAR, NLR, PLR, and mGPS, respectively. According to the estimated threshold, high CAR, NLR, PLR, and mGPS were associated with increased one-year mortality (1.7% vs. 11.7%, hazard ratio [HR]: 2.38, 95% CI [2.05, 2.76], P < 0.001 for CAR; 2.2% vs. 10.3%, HR: 1.81, 95% CI [1.62, 2.03], P < 0.001 for NLR; 2.6% vs. 10.5%, HR: 1.86, 95% CI [1.73, 2.01], P < 0.001 for PLR; and 2.3% vs. 16.3%, HR: 2.37, 95% CI [2.07, 2.72], P < 0.001 for mGPS).

Conclusions: Preoperative CAR, NRL, PLR, and mGPS were associated with postoperative mortality. Our findings may be helpful in predicting mortality after non-cardiac surgery.

基于炎症的预后指标与非心脏手术死亡率之间的关系。
背景:评估炎症和基于营养的生物标志物与非心脏手术后预后之间的关系。方法:在2011年1月至2019年6月期间,共评估了102052例接受非心脏手术的患者,在术前6个月内测量了c反应蛋白(CRP)、白蛋白和全血细胞计数(CBC)。我们评估了他们的crp -白蛋白比率(CAR)、中性粒细胞-淋巴细胞比率(NLR)、血小板-淋巴细胞比率(PLR)和改良格拉斯哥预后评分(mGPS)。我们利用受试者工作特征(ROC)曲线确定最佳临界值。根据估计阈值将患者分为高、低两组,比较1年死亡率。结果:整个样本一年死亡率为4.2%。ROC分析显示,CAR、NLR、PLR和mGPS的曲线下面积分别为0.796、0.743、0.670和0.708。根据估计阈值,高CAR、NLR、PLR和mGPS与一年死亡率增加相关(1.7% vs. 11.7%,风险比[HR]: 2.38, 95% CI [2.05, 2.76], CAR的P < 0.001;2.2%比10.3%,HR: 1.81, 95% CI [1.62, 2.03], NLR P < 0.001;PLR为2.6%比10.5%,HR: 1.86, 95% CI [1.73, 2.01], P < 0.001;2.3%对16.3%,HR: 2.37, 95% CI [2.07, 2.72], mGPS组P < 0.001)。结论:术前CAR、NRL、PLR和mGPS与术后死亡率相关。我们的发现可能有助于预测非心脏手术后的死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.20
自引率
6.90%
发文量
84
审稿时长
16 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信