Peripheral Inflammatory Markers in Subtypes and Core Features of Depression: A Systematized Review.

IF 1.9 3区医学 Q3 PSYCHIATRY

Psychopathology Pub Date : 2023-01-01 Epub Date: 2023-02-22 DOI:10.1159/000528907

Pavel Křenek, Jana Hořínková, Elis Bartečků

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引用次数: 2

Abstract

Introduction: The aim of this work was to summarize relationships between two subtypes of major depressive disorder (melancholic and atypical) and four core features of depression that reflect the domains identified consistently in previous studies of major depressive disorder endophenotypes (exaggerated reactivity to negative information, altered reward processing, cognitive control deficits, and somatic symptoms) on the one hand and selected peripheral inflammatory markers (C-reactive protein [CRP], cytokines, and adipokines) on the other.

Methods: A systematized review was conducted. The database used for searching articles was PubMed (MEDLINE).

Results: According to our search, most peripheral immunological markers associated with major depressive disorder are not specific to a single depressive symptom group. The most evident examples are CRP, IL-6, and TNF-α. The strongest evidence supports the connection of peripheral inflammatory markers with somatic symptoms; weaker evidence indicates a role of immune changes in altered reward processing. The least amount of evidence was found for the role of peripheral inflammatory markers in exaggerated reactivity to negative information and cognitive control deficits. Regarding the depression subtypes, a tendency for higher CRP and adipokines was observed in atypical depression; increased IL-6 was found in melancholic depression.

Conclusion: Somatic symptoms of depression could be a manifestation of a specific immunological endophenotype of depressive disorder. Melancholic and atypical depression may be characterized by different profiles of immunological markers.

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抑郁症亚型和核心特征的外周炎症标志物：系统综述。

引言：这项工作的目的是总结两种严重抑郁障碍亚型（忧郁症和非典型）与抑郁症四个核心特征之间的关系，这些特征反映了先前对严重抑郁障碍内在表型的研究中一致确定的领域一方面是对负面信息的过度反应、奖励处理的改变、认知控制缺陷和躯体症状），另一方面是选定的外周炎症标志物（C反应蛋白[CRP]、细胞因子和脂肪因子）。方法：进行系统综述。用于搜索文章的数据库是PubMed（MEDLINE）。结果：根据我们的搜索，大多数与重度抑郁障碍相关的外周免疫标志物并不是单一抑郁症状组特有的。最明显的例子是CRP、IL-6和TNF-α。最有力的证据支持外周炎症标志物与躯体症状的联系；较弱的证据表明，免疫变化在改变奖励过程中发挥了作用。外周炎症标志物在对负面信息的过度反应和认知控制缺陷中的作用证据最少。关于抑郁症亚型，在非典型抑郁症中观察到CRP和脂肪因子升高的趋势；在忧郁症抑郁症中发现IL-6升高。结论：抑郁症的躯体症状可能是抑郁症的一种特异性免疫内表型的表现。忧郁症和非典型抑郁症可能以不同的免疫标志物为特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychopathology 医学-精神病学

CiteScore

5.10

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： ''Psychopathology'' is a record of research centered on findings, concepts, and diagnostic categories of phenomenological, experimental and clinical psychopathology. Studies published are designed to improve and deepen the knowledge and understanding of the pathogenesis and nature of psychopathological symptoms and psychological dysfunctions. Furthermore, the validity of concepts applied in the neurosciences of mental functions are evaluated in order to closely bring together the mind and the brain. Major topics of the journal are trajectories between biological processes and psychological dysfunction that can help us better understand a subject’s inner experiences and interpersonal behavior. Descriptive psychopathology, experimental psychopathology and neuropsychology, developmental psychopathology, transcultural psychiatry as well as philosophy-based phenomenology contribute to this field.