Inflammasomes in Human Immunodeficiency Virus Type 1 Infection.

Qiankun Wang, Liang Shan
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引用次数: 1

Abstract

Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral responses. In response to HIV-1 nucleic acids or proteins, some pattern recognition receptors have the ability to assemble a large multiprotein complex called the inflammasome, which triggers pro-inflammatory cytokine release and a form of lytic programmed cell death called pyroptosis. Here, we review our current understanding of the mechanism of the inflammasome in sensing HIV-1 infection. Furthermore, we discuss the contribution of inflammasome activation in HIV-1 pathogenesis as well as potential strategies of targeting inflammasome activation for the treatment of HIV-1 infection.

Abstract Image

人类免疫缺陷病毒1型感染中的炎性小体。
先天免疫反应是宿主抵御人类免疫缺陷病毒1型(HIV-1)感染的第一道防线,模式识别受体检测病毒特异性病原体相关的分子模式并启动抗病毒反应。在对HIV-1核酸或蛋白质的反应中,一些模式识别受体有能力组装一个称为炎性小体的大型多蛋白复合物,从而触发促炎细胞因子释放和一种称为焦亡的溶解性程序性细胞死亡形式。在这里,我们回顾了我们目前对炎症小体感知HIV-1感染的机制的理解。此外,我们讨论了炎症小体激活在HIV-1发病机制中的作用,以及靶向炎症小体激活治疗HIV-1感染的潜在策略。
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