Laura van Iersel, Renee L Mulder, Christian Denzer, Laurie E Cohen, Helen A Spoudeas, Lillian R Meacham, Elaine Sugden, Antoinette Y N Schouten-van Meeteren, Eelco W Hoving, Roger J Packer, Gregory T Armstrong, Sogol Mostoufi-Moab, Aline M Stades, Dannis van Vuurden, Geert O Janssens, Cécile Thomas-Teinturier, Robert D Murray, Natascia Di Iorgi, Sebastian J C M M Neggers, Joel Thompson, Andrew A Toogood, Helena Gleeson, Cecilia Follin, Edit Bardi, Lilibeth Torno, Briana Patterson, Vera Morsellino, Grit Sommer, Sarah C Clement, Deokumar Srivastava, Cecilie E Kiserud, Alberto Fernandez, Katrin Scheinemann, Sripriya Raman, Kevin C J Yuen, W Hamish Wallace, Louis S Constine, Roderick Skinner, Melissa M Hudson, Leontien C M Kremer, Wassim Chemaitilly, Hanneke M van Santen
{"title":"Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors.","authors":"Laura van Iersel, Renee L Mulder, Christian Denzer, Laurie E Cohen, Helen A Spoudeas, Lillian R Meacham, Elaine Sugden, Antoinette Y N Schouten-van Meeteren, Eelco W Hoving, Roger J Packer, Gregory T Armstrong, Sogol Mostoufi-Moab, Aline M Stades, Dannis van Vuurden, Geert O Janssens, Cécile Thomas-Teinturier, Robert D Murray, Natascia Di Iorgi, Sebastian J C M M Neggers, Joel Thompson, Andrew A Toogood, Helena Gleeson, Cecilia Follin, Edit Bardi, Lilibeth Torno, Briana Patterson, Vera Morsellino, Grit Sommer, Sarah C Clement, Deokumar Srivastava, Cecilie E Kiserud, Alberto Fernandez, Katrin Scheinemann, Sripriya Raman, Kevin C J Yuen, W Hamish Wallace, Louis S Constine, Roderick Skinner, Melissa M Hudson, Leontien C M Kremer, Wassim Chemaitilly, Hanneke M van Santen","doi":"10.1210/endrev/bnab040","DOIUrl":null,"url":null,"abstract":"<p><p>Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG surveillance recommendations for premature ovarian insufficiency, gonadotoxicity in males, fertility preservation, and thyroid cancer are summarized. For hypothalamic-pituitary (HP) dysfunction, new surveillance recommendations were formulated by a guideline panel consisting of 42 interdisciplinary international experts. A systematic literature search was performed in MEDLINE (through PubMed) for clinically relevant questions concerning HP dysfunction. Literature was screened for eligibility. Recommendations were formulated by drawing conclusions from quality assessment of all evidence, considering the potential benefits of early detection and appropriate management. Healthcare providers should be aware that CAYA cancer survivors have an increased risk for endocrine disorders, including HP dysfunction. Regular surveillance with clinical history, anthropomorphic measures, physical examination, and laboratory measurements is recommended in at-risk survivors. When endocrine disorders are suspected, healthcare providers should proceed with timely referrals to specialized services. These international evidence-based recommendations for surveillance of endocrine disorders in CAYA cancer survivors inform healthcare providers and highlight the need for long-term endocrine follow-up care in subgroups of survivors and elucidate opportunities for further research.</p>","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":null,"pages":null},"PeriodicalIF":22.0000,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/endrev/bnab040","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 13
Abstract
Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG surveillance recommendations for premature ovarian insufficiency, gonadotoxicity in males, fertility preservation, and thyroid cancer are summarized. For hypothalamic-pituitary (HP) dysfunction, new surveillance recommendations were formulated by a guideline panel consisting of 42 interdisciplinary international experts. A systematic literature search was performed in MEDLINE (through PubMed) for clinically relevant questions concerning HP dysfunction. Literature was screened for eligibility. Recommendations were formulated by drawing conclusions from quality assessment of all evidence, considering the potential benefits of early detection and appropriate management. Healthcare providers should be aware that CAYA cancer survivors have an increased risk for endocrine disorders, including HP dysfunction. Regular surveillance with clinical history, anthropomorphic measures, physical examination, and laboratory measurements is recommended in at-risk survivors. When endocrine disorders are suspected, healthcare providers should proceed with timely referrals to specialized services. These international evidence-based recommendations for surveillance of endocrine disorders in CAYA cancer survivors inform healthcare providers and highlight the need for long-term endocrine follow-up care in subgroups of survivors and elucidate opportunities for further research.
期刊介绍:
Endocrine Reviews, published bimonthly, features concise timely reviews updating key mechanistic and clinical concepts, alongside comprehensive, authoritative articles covering both experimental and clinical endocrinology themes. The journal considers topics informing clinical practice based on emerging and established evidence from clinical research. It also reviews advances in endocrine science stemming from studies in cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.