Dietary Folate, Vitamin B6, and Vitamin B12 and Risk of Cardiovascular Diseases among Individuals with Type 2 Diabetes: A Case-Control Study.

IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Shangling Wu, Pinning Feng, Wanlin Li, Shuyu Zhuo, Wei Lu, Peiyan Chen, Yi Sui, Shi Fang, Zhongyi Yang, Yanbin Ye
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引用次数: 4

Abstract

Background: Emerging evidence suggests that dietary one-carbon metabolism-related B-vitamins are associated with the reduced risk of cardiovascular disease (CVD) in the general population. However, only a few studies have assessed their associations in patients with type 2 diabetes (T2D).

Objective: This study aimed to assess the associations between the intake of three one-carbon metabolism-related B-vitamins (folate, vitamin B6, and vitamin B12) and CVD risk in Chinese patients with T2D.

Methods: A hospital-based case-control study of 419 patients with T2D and newly diagnosed CVD and 419 age- (±5 years) and sex-matched T2D-only controls was carried out in China. A validated 79-item semi-quantitative food-frequency questionnaire administered in face-to-face interviews was used to measure dietary B-vitamin intake. Conditional logistic regression was used to assess associations, which were tested by estimating odds ratios (ORs) with 95% confidence intervals (CIs).

Results: Compared with the lowest quartile, the multivariable-adjusted ORs and 95% CIs for highest quartile were 0.32 (95% CI: 0.20, 0.52; p trend <0.001) for folate, 0.47 (95% CI: 0.30, 0.76; p trend = 0.002) for vitamin B6, and 1.02 (95% CI: 0.67, 1.55; p trend = 0.841) for vitamin B12. Consistent inverse associations were found for folate intake from eggs, vegetables, fruits, soy, and other foods but not for folate intake from grains.

Conclusions: Findings suggest that the high consumption of folate and vitamin B6, but not that of vitamin B12, might be associated with the low risk of CVD in patients with T2D. This study suggests that dietary folate and vitamin B6 protect against CVD in patients with T2D.

2型糖尿病患者饮食中叶酸、维生素B6和维生素B12与心血管疾病的风险:一项病例对照研究
背景:新出现的证据表明,在普通人群中,饮食中与单碳代谢相关的b族维生素与心血管疾病(CVD)风险降低有关。然而,只有少数研究评估了它们与2型糖尿病(T2D)患者的关系。目的:本研究旨在评估中国t2dm患者三种单碳代谢相关b族维生素(叶酸、维生素B6和维生素B12)的摄入与CVD风险之间的关系。方法:在中国开展一项基于医院的病例对照研究,其中419例T2D合并新诊断的CVD患者和419例年龄(±5岁)和性别匹配的T2D对照组。一份经过验证的79项半定量食物频率问卷在面对面访谈中被用来测量饮食中b族维生素的摄入量。使用条件逻辑回归来评估相关性,并通过估计95%置信区间(ci)的比值比(ORs)进行检验。结果:与最低四分位数相比,最高四分位数的多变量调整ORs和95% CI为0.32 (95% CI: 0.20, 0.52;结论:研究结果表明,高叶酸和维生素B6的摄入,而不是维生素B12的摄入,可能与T2D患者心血管疾病的低风险有关。本研究提示,饮食中叶酸和维生素B6对T2D患者的心血管疾病有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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