Exploring Intra-arterial Contrast Administration for Intraoperative Imaging Using a Swine Model.

IF 2.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Angiology Pub Date : 2025-10-01 Epub Date: 2023-02-08 DOI:10.1177/00033197231155225
Rebecca N Treffalls, Kelly Poe, Hossam Abdou, David P Stonko, Joseph Edwards, Randall R DeMartino, Thomas Ptak, Jonathan J Morrison
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引用次数: 0

Abstract

Intraoperative computed tomography (CT) imaging with endovascular delivery of intra-arterial (IA) contrast could potentially provide higher attenuation with lower contrast volumes than intravenous (IV) administration. We aimed to compare IA and IV contrast use for organ-specific CT abdominal imaging. Five anesthetized swine had external jugular and brachial artery access with ascending aortic pigtail placement. An IV protocol was 100 mL at 5 mL/sec over 20 sec vs 50 mL of IA contrast at 5 mL/sec over 10 sec. Region-of-interest markers were applied to anatomical regions to measure attenuation (HU) over time. IA and IV contrast protocols achieved adequate aortic opacification (IA, 455 ± 289 vs IV, 450 ± 114 HU). The IA contrast aortic attenuation curve reached peak attenuation compared with IV contrast (IA, 8 vs 23 sec; P < .001). Time to peak attenuation was similar between IA and IV contrast in the portal vein (IA, 38 vs IV, 42 sec, P = .25). IA administration achieved a superior contrast-to-noise ratio (CNR) in less time compared with IV (R2 = .94; P < .001). IA contrast achieved adequate opacification with less bolus broadening and a superior CNR compared with IV contrast while using a smaller contrast volume for directed organ-directed imaging.

利用猪模型探索用于术中成像的动脉内造影剂。
与静脉注射造影剂相比,通过血管内注射动脉内造影剂进行术中计算机断层扫描(CT)成像有可能以较低的造影剂用量提供更高的衰减。我们旨在比较腹部特定器官 CT 成像中 IA 和 IV 造影剂的使用情况。五头麻醉猪通过颈外动脉和肱动脉进入腹腔,并放置了升主动脉纤尾。静脉注射方案为 100 毫升,每秒 5 毫升,持续 20 秒;IA 造影剂为 50 毫升,每秒 5 毫升,持续 10 秒。在解剖区域应用感兴趣区标记来测量随时间变化的衰减(HU)。IA和IV造影剂方案都能达到足够的主动脉透亮度(IA,455 ± 289 vs IV,450 ± 114 HU)。与静脉注射对比剂相比,IA对比剂主动脉衰减曲线达到衰减峰值(IA,8秒 vs 23秒;P < .001)。门静脉 IA 和 IV 造影剂达到峰值衰减的时间相似(IA:38 秒;IV:42 秒;P = .25)。与静脉注射造影剂相比,IA造影剂能在更短的时间内达到更高的对比度-噪声比(CNR)(R2 = .94; P < .001)。与静脉注射造影剂相比,IA 造影剂可在较小的造影剂量下实现充分的不透明性,同时减少栓子扩大,并获得更高的对比度-噪音比(CNR),从而实现器官定向成像。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Angiology
Angiology 医学-外周血管病
CiteScore
5.50
自引率
14.30%
发文量
180
审稿时长
6-12 weeks
期刊介绍: A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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