Dexamethasone-Induced Arterial Stiffening Is Attenuated by Training due to a Better Balance Between Aortic Collagen and Elastin Levels.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Drugs and Therapy Pub Date : 2024-08-01 Epub Date: 2023-02-16 DOI:10.1007/s10557-023-07438-z

Vinicius F de Paula, Lidieli P Tardelli, Sandra L Amaral

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引用次数: 0

Abstract

Purpose: Although the cardioprotective benefits of exercise training are well known, the effects of training on dexamethasone (DEX)-induced arterial stiffness are still unclear. This study was aimed at investigating the mechanisms induced by training to prevent DEX-induced arterial stiffness.

Methods: Wistar rats were allocated into 4 groups and submitted to combined training (aerobic and resistance exercises, on alternate days, 60% of maximal capacity, for 74 d) or were kept sedentary: sedentary control rats (SC), DEX-treated sedentary rats (DS), combined training control (CT), and DEX-treated trained rats (DT). During the last 14 d, rats were treated with DEX (50 μg/kg per body weight, per day, s.c.) or saline.

Results: DEX increased PWV (+44% vs +5% m/s, for DS vs SC, p<0.001) and increased aortic COL 3 protein level (+75%) in DS. In addition, PWV was correlated with COL3 levels (r=0.682, p<0.0001). Aortic elastin and COL1 protein levels remained unchanged. On the other hand, the trained and treated groups showed lower PWV values (-27% m/s, p<0.001) vs DS and lower values of aortic and femoral COL3 compared with DS.

Conclusion: As DEX is widely used in several situations, the clinical relevance of this study is that the maintenance of good physical capacity throughout life can be crucial to alleviate some of its side effects, such as arterial stiffness.

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由于主动脉胶原蛋白和弹性蛋白水平之间的平衡得到改善，地塞米松诱发的动脉僵化会因训练而减弱。

目的：尽管运动训练对心脏的保护作用已众所周知，但训练对地塞米松（DEX）诱导的动脉僵化的影响仍不清楚。本研究旨在探讨训练预防地塞米松诱发动脉僵化的机制：将 Wistar 大鼠分为 4 组，分别进行联合训练（有氧运动和阻力运动，隔天进行，最大运动量的 60%，持续 74 天）或保持静坐：静坐对照组（SC）、DEX 处理的静坐大鼠（DS）、联合训练对照组（CT）和 DEX 处理的训练大鼠（DT）。在最后 14 天，大鼠接受 DEX（50 μg/kg 每公斤体重，每天，皮下注射）或生理盐水治疗：结果：DEX 增加了脉搏波速度（DS 与 SC 相比，+44% 与 +5% m/s，p）：由于 DEX 被广泛应用于多种情况，本研究的临床意义在于，终生保持良好的体能对于减轻 DEX 的一些副作用（如动脉僵化）至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Drugs and Therapy 医学-心血管系统

CiteScore

8.30

自引率

0.00%

发文量

110

审稿时长

4.5 months

期刊介绍： Designed to objectively cover the process of bench to bedside development of cardiovascular drug, device and cell therapy, and to bring you the information you need most in a timely and useful format, Cardiovascular Drugs and Therapy takes a fresh and energetic look at advances in this dynamic field. Homing in on the most exciting work being done on new therapeutic agents, Cardiovascular Drugs and Therapy focusses on developments in atherosclerosis, hyperlipidemia, diabetes, ischemic syndromes and arrhythmias. The Journal is an authoritative source of current and relevant information that is indispensable for basic and clinical investigators aiming for novel, breakthrough research as well as for cardiologists seeking to best serve their patients. Providing you with a single, concise reference tool acknowledged to be among the finest in the world, Cardiovascular Drugs and Therapy is listed in Web of Science and PubMed/Medline among other abstracting and indexing services. The regular articles and frequent special topical issues equip you with an up-to-date source defined by the need for accurate information on an ever-evolving field. Cardiovascular Drugs and Therapy is a careful and accurate guide through the maze of new products and therapies which furnishes you with the details on cardiovascular pharmacology that you will refer to time and time again.