Moving beyond the mean: Promising research pathways to support a precision medicine approach to hormonal contraception

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI:10.1016/j.yfrne.2022.101042

Sarah E. Hill , Summer Mengelkoch

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引用次数: 5

Abstract

Women’s psychological and behavioral responses to hormonal contraceptive (HC) treatment can be highly variable. One of the great challenges to researchers seeking to improve the experiences of women who use HCs is to identify the sources of this variability to minimize unpleasant psychobehavioral side-effects. In the following, we provide recommendations for programs of research aimed at identifying sources of heterogeneity in women’s experiences with HC. First, we review research demonstrating person- and prescription- based heterogeneity in women’s psychobehavioral responses to HCs. Next, we identify several promising person- and prescription- based sources of this heterogeneity that warrant future research. We close with a discussion of research approaches that are particularly well-suited to address the research questions raised in article. Together, this review provides researchers with several promising research pathways to help support the development of a precision medicine approach to HC treatment.

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超越平均值:有希望的研究途径，以支持精确医学方法激素避孕

女性对激素避孕（HC）治疗的心理和行为反应可能存在很大差异。寻求改善使用HCs女性体验的研究人员面临的一大挑战是确定这种变异性的来源，以最大限度地减少令人不快的心理行为副作用。在下文中，我们为旨在确定女性HC经历异质性来源的研究项目提供了建议。首先，我们回顾了研究表明，在女性对HC的心理行为反应中，基于个人和处方的异质性。接下来，我们确定了这种异质性的几个有前景的基于个人和处方的来源，这些来源值得未来的研究。最后，我们将讨论特别适合于解决文章中提出的研究问题的研究方法。总之，这篇综述为研究人员提供了几种有前景的研究途径，以帮助支持HC治疗的精确医学方法的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.