The impact of depression on language function in individuals with Alzheimer's disease: a pre/post-treatment design.

IF 3.6 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2023-02-03 DOI:10.1186/s12991-023-00433-6

Kyung Hee Yoon, Yoo Sun Moon, Do Hoon Kim

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引用次数: 0

Abstract

Background: It is uncertain whether depression might affect cognitive function in Alzheimer's disease (AD). Most of studies on the effect of depression treatment on cognitive function in AD were briefly evaluated by Mini-Mental State Examination (MMSE). MMSE is poor sensitive to detect cognitive change. This study examined the cognitive response to depression treatment in AD via multi-domain assessment. In addition, we explored whether effect of depression treatment in AD is different those of late-life depression (LLD).

Methods: This study include AD patients with depression (AD + D) and without depression (AD - D), LLD patients (LLD), and healthy controls (HC). The patients were treated according to their diagnosis for 16 weeks: acetylcholinesterase inhibitors (AChEIs) and selective serotonin reuptake inhibitors (SSRIs) for AD + D, AChEIs for AD - D, and SSRIs for LLD. The cognitive changes from pre- to post-treatment were compared between AD + D and AD - D or LLD and HC. An independent sample t test was performed to compare the degree of change between the groups. Paired t tests were used to determine cognitive function changes in each depression treatment responder group.

Results: At baseline, AD + D had more impairment in language function compared to AD - D, and LLD had greater deficit in executive function than HC. After depression treatment, more impaired cognitive domains at baseline were improved in AD + D and LLD, respectively. Moreover, AD + D showed an improvement in the global cognitive function (MMSE).

Conclusions: Results indicated that language function was influenced by depression in AD, which is first evidence for specific cognitive domain related to depression in AD. Our finding indicates that depression could negatively impact cognitive function, and depression treatment may have beneficial cognitive effect in both AD and LLD. This study suggests the importance of early detection and treatment of depression in AD and LLD. Trial registration Clinical Research Information Service, CRIS, ID#: KCT0004041, Registered 5 June 2019, retrospectively registered after first patient enrollment date (4 March 2014) https://cris.nih.go.kr/cris/search/detailSearch.do?seq=14140&status=5&seq_group=14140&search_page=M .

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抑郁症对阿尔茨海默病患者语言功能的影响:治疗前/治疗后设计

背景:尚不清楚抑郁症是否会影响阿尔茨海默病(AD)患者的认知功能。大多数关于抑郁症治疗对阿尔茨海默病患者认知功能影响的研究都是通过简易精神状态检查(MMSE)来简单评估的。MMSE检测认知变化的敏感性较差。本研究通过多领域评估考察了AD患者对抑郁治疗的认知反应。此外，我们还探讨了抑郁症治疗在老年痴呆症中的效果是否与老年抑郁症(LLD)不同。方法:本研究包括伴有抑郁(AD + D)和无抑郁(AD - D)的AD患者、LLD患者(LLD)和健康对照组(HC)。患者根据诊断接受16周的治疗:针对AD + D使用乙酰胆碱酯酶抑制剂(AChEIs)和选择性5 -羟色胺再摄取抑制剂(SSRIs)，针对AD - D使用AChEIs，针对LLD使用SSRIs。比较AD + D和AD - D或LLD和HC治疗前后的认知变化。采用独立样本t检验比较各组间的变化程度。配对t检验用于确定每个抑郁症治疗反应组的认知功能变化。结果:在基线时，AD + D比AD - D有更多的语言功能障碍，LLD比HC有更大的执行功能缺陷。抑郁症治疗后，AD + D和LLD患者在基线时受损的认知域分别得到改善。此外，AD + D还能改善整体认知功能(MMSE)。结论:阿尔茨海默病患者抑郁情绪对语言功能有影响，这是阿尔茨海默病患者抑郁情绪相关的特定认知领域的首次证据。我们的研究结果表明，抑郁症可能会对认知功能产生负面影响，抑郁症治疗可能对AD和LLD的认知功能都有有益的影响。本研究提示在AD和LLD中早期发现和治疗抑郁的重要性。临床研究信息服务，CRIS, ID#: KCT0004041，注册于2019年6月5日，回顾性注册于首次患者入组日期(2014年3月4日)https://cris.nih.go.kr/cris/search/detailSearch.do?seq=14140&status=5&seq_group=14140&search_page=M。

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来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.