A high CMV-specific T cell response associates with SARS-CoV-2-specific IL-17 T cell production.

IF 5.5 3区医学 Q1 IMMUNOLOGY

Medical Microbiology and Immunology Pub Date : 2023-02-01 DOI:10.1007/s00430-022-00758-1

Fernanda Tereza Bovi Frozza, Tiago Fazolo, Priscila Oliveira de Souza, Karina Lima, Julia Crispim da Fontoura, Théo Souza Borba, Márcia Polese-Bonatto, Luciane Beatriz Kern, Renato T Stein, Graham Pawelec, Cristina Bonorino

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引用次数: 2

Abstract

Human cytomegalovirus (CMV) is a widespread persistent herpes virus requiring lifelong immune surveillance to maintain latency. Such long-term interactions with the immune system may be associated with deleterious effects including immune exhaustion and senescence. Regarding the COVID-19 pandemic, we asked whether CMV-specific cellular and humoral activity could influence immune responses toward SARS-CoV-2 and/or disease severity. All adults with mild (n = 15) and severe (n = 14) COVID-19 were seropositive for anti-CMV IgG, but negative for IgM antibodies. Antibody titers did not correlate with COVID-19 severity. Six patients presented elevated frequencies of CMV-specific CD4 + and CD8 + T cells producing IFNγ, IL-17, and TNFα, designated as CMV high responders (hiT CMV). In comparison to low CMV responders, hiT CMV individuals exhibited higher frequencies of SARS-CoV-2-specific CD4 + IL-17 + and CD8 + IFNγ + , IL-17 + or TNFα + T cells. These results indicate that high frequencies of CMV-specific T cells may be associated with a SARS-CoV-2-reactive profile skewed toward Th17-dominated immunity.

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高cmv特异性T细胞应答与sars - cov -2特异性IL-17 T细胞产生相关

人巨细胞病毒(CMV)是一种广泛存在的持续性疱疹病毒，需要终生免疫监测以维持潜伏期。这种与免疫系统的长期相互作用可能与包括免疫衰竭和衰老在内的有害影响有关。关于COVID-19大流行，我们询问cmv特异性细胞和体液活性是否会影响对SARS-CoV-2和/或疾病严重程度的免疫反应。所有患有轻度(n = 15)和重度(n = 14) COVID-19的成人血清抗cmv IgG阳性，但IgM抗体阴性。抗体滴度与COVID-19严重程度无关。6例患者出现CMV特异性CD4 +和CD8 + T细胞产生IFNγ、IL-17和TNFα的频率升高，被称为CMV高应答者(hiT CMV)。与低CMV应答者相比，hiT CMV个体表现出更高的sars - cov -2特异性CD4 + IL-17 +和CD8 + ifn - γ +， IL-17 +或tnf - α + T细胞频率。这些结果表明，cmv特异性T细胞的高频率可能与sars - cov -2反应谱倾向于th17主导的免疫有关。

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来源期刊

Medical Microbiology and Immunology 医学-免疫学

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Medical Microbiology and Immunology (MMIM) publishes key findings on all aspects of the interrelationship between infectious agents and the immune system of their hosts. The journal´s main focus is original research work on intrinsic, innate or adaptive immune responses to viral, bacterial, fungal and parasitic (protozoan and helminthic) infections and on the virulence of the respective infectious pathogens. MMIM covers basic, translational as well as clinical research in infectious diseases and infectious disease immunology. Basic research using cell cultures, organoid, and animal models are welcome, provided that the models have a clinical correlate and address a relevant medical question. The journal also considers manuscripts on the epidemiology of infectious diseases, including the emergence and epidemic spreading of pathogens and the development of resistance to anti-infective therapies, and on novel vaccines and other innovative measurements of prevention. The following categories of manuscripts will not be considered for publication in MMIM: submissions of preliminary work, of merely descriptive data sets without investigation of mechanisms or of limited global interest, manuscripts on existing or novel anti-infective compounds, which focus on pharmaceutical or pharmacological aspects of the drugs, manuscripts on existing or modified vaccines, unless they report on experimental or clinical efficacy studies or provide new immunological information on their mode of action, manuscripts on the diagnostics of infectious diseases, unless they offer a novel concept to solve a pending diagnostic problem, case reports or case series, unless they are embedded in a study that focuses on the anti-infectious immune response and/or on the virulence of a pathogen.