Adherence to Typical Antipsychotics among Patients with Schizophrenia in Uganda: A Cross-Sectional Study.

IF 3.6 Q1 PSYCHIATRY
Schizophrenia Research and Treatment Pub Date : 2023-02-03 eCollection Date: 2023-01-01 DOI:10.1155/2023/7035893
Moses Kule, Mark Mohan Kaggwa
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引用次数: 0

Abstract

Background: There has been a recent transition from typical to atypical antipsychotics in managing schizophrenia. This has been attributed to the acute side effects experienced by patients on typical antipsychotics that lead to nonadherence. However, the treatment cost with typical antipsychotics is cheaper (preferred in low-income settings), and there is no difference in the effectiveness, efficacy, discontinuation rate, or side effect symptom burden with atypical antipsychotics. This study is aimed at determining the prevalence of nonadherence and the associated factors to typical antipsychotics among patients with schizophrenia attending a psychiatric outpatient clinic at a rural tertiary facility in Uganda.

Method: A cross-sectional study among 135 patients with schizophrenia for at least six months on typical antipsychotics (mean age of 39.7 (±11.9) and 55.6% were female) from a rural tertiary facility in Uganda. Data were collected regarding sociodemographics, adherence, insight for psychosis, attitude towards typical antipsychotics, side effects, satisfaction with medications, and explanations from health workers about medications and side effects. Logistic regression was used to determine the factors associated with nonadherence.

Results: The prevalence of nonadherence was 16.3%, and the likelihood of being nonadherent was more among the poor (monthly earning below the poverty line). However, having reduced energy was associated with reducing the likelihood of having nonadherence.

Conclusion: The prevalence of nonadherence was lower than many previously obtained prevalence and was comparable to nonadherence for atypical antipsychotics. However, to reduce nonadherence, we need all stakeholders (such as the government, insurance companies, and caregivers) to assist patients living in poverty with access to medication.

乌干达精神分裂症患者对典型抗精神病药物的依从性:一项横断面研究。
背景:在治疗精神分裂症方面,最近出现了从典型抗精神病药物向非典型抗精神病药物过渡的趋势。这是因为服用典型抗精神病药物的患者会出现急性副作用,导致患者不坚持治疗。然而,使用典型抗精神病药物的治疗成本更低(低收入环境中的首选),而且非典型抗精神病药物在有效性、疗效、停药率或副作用症状负担方面没有差异。本研究旨在确定在乌干达农村三级医疗机构精神科门诊就诊的精神分裂症患者对典型抗精神病药物不依从的发生率及相关因素:对乌干达一家农村三级医疗机构的 135 名服用典型抗精神病药物至少六个月的精神分裂症患者(平均年龄为 39.7 岁 (±11.9),55.6% 为女性)进行横断面研究。收集的数据涉及社会人口学、依从性、对精神病的洞察力、对典型抗精神病药物的态度、副作用、对药物的满意度以及医护人员对药物和副作用的解释。采用逻辑回归法确定与不依从性相关的因素:不坚持服药的比例为 16.3%,穷人(月收入低于贫困线)不坚持服药的可能性更大。然而,能量减少与降低不坚持服药的可能性有关:结论:不依从的发生率低于许多以前获得的发生率,与不依从非典型抗精神病药物的发生率相当。然而,为了减少不依从性,我们需要所有利益相关者(如政府、保险公司和护理人员)帮助贫困患者获得药物治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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