[Expression of estrogen and progesterone receptors in vestibular schwannomas].

Q4 Medicine

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2023-01-01 DOI:10.17116/neiro20238701144

S R Ilyalov, M V Ryzhova, M V Galkin, S M Banov, A V Golanov, D Yu Usachev

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引用次数: 3

Abstract

Introduction: Stereotactic radiosurgery is one of the main treatments for vestibular schwannomas (VS). Their feature is frequent post-radiation pseudoprogression. This may be due to hormonal status of patients.

Objective: To analyze expression of progesterone and estrogen receptors in women and men with VS.

Material and methods: Immunohistochemical analysis of expression of progesterone (PR) and estrogen receptors (ER) after biopsy was performed in 240 patients with VS between 2018 and 2021. ER/PR expression was assessed in men (n=120) and women (n=120) in 3 age subgroups: young age (18-44 years), middle age (45-59 years) and old age (60-79 years). Each subgroup included 40 patients. Statistical analysis was performed using the Mann-Whitney test and MedCalc software.

Results: ER expression is not typical for VS (men - 1 (0.01%), women - 3 (2.5%)). At the same time, PR expression was found in 29 (24.2%) men and 21 (17.5%) women. We found no significant difference in expression of ER and PR between men and women. However, variability in PR expression was revealed, i.e. predominance of this indicator in young women (p=0.0463) and middle-aged men (p=0.0110). Expression of PR was similar in elderly patients (p=0.2382).

Conclusion: The established incidence of PR expression may be one of the probable causes affecting development and duration of VS pseudoprogression after radiosurgery without clear relationship between sex and age. Further prospective research is needed to predict the risks of pseudoprogression.

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雌激素和孕激素受体在前庭神经鞘瘤中的表达。

立体定向放射外科是治疗前庭神经鞘瘤的主要方法之一。其特点是放射后假性进展频繁。这可能与患者的激素状况有关。目的:分析女性和男性VS患者中孕激素和雌激素受体的表达。材料和方法:对2018年至2021年240例VS患者进行活检后孕激素(PR)和雌激素受体(ER)的免疫组织化学表达分析。在青年(18-44岁)、中年(45-59岁)和老年(60-79岁)3个年龄亚组中，对男性(n=120)和女性(n=120)进行ER/PR表达评估。每个亚组包括40例患者。采用Mann-Whitney检验和MedCalc软件进行统计分析。结果:ER在VS中表达不典型(男性- 1(0.01%)，女性- 3(2.5%))。男性29例(24.2%)，女性21例(17.5%)。我们发现男女之间ER和PR的表达无显著差异。然而，PR表达的变异性被揭示出来，即该指标在年轻女性(p=0.0463)和中年男性(p=0.0110)中占优势。老年患者PR表达相似(p=0.2382)。结论:PR表达发生率的确定可能是影响放疗后VS假性进展的发生和持续时间的原因之一，性别和年龄无明确关系。需要进一步的前瞻性研究来预测假性进展的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Medicine-Neurology (clinical)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： Scientific and practical peer-reviewed journal. This publication covers the theoretical, practical and organizational problems of modern neurosurgery, the latest advances in the treatment of various diseases of the central and peripheral nervous system. Founded in 1937. English version of the journal translates from Russian version since #1/2013.