Evaluation of Parenteral Potassium Supplementation in Pediatric Patients.

Q2 Medicine
Amanda A Clouser, Cristian D Merchan, Ferras Bashqoy, Joanna L Tracy, John Papadopoulos, Anasemon Saad
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引用次数: 1

Abstract

Objective: The primary objective was to evaluate the effect of parenteral potassium chloride (KCl) supplementation on potassium (K+) concentrations in a non-cardiac pediatric population. Secondary outcomes were to identify variables that may influence response to KCl supplementation (i.e., change in K+ concentration after KCl administration) and assess the incidence of hyperkalemia.

Methods: This single-center, retrospective study evaluated infants and children who received parenteral KCl supplementation of 0.5 or 1 mEq/kg between January 2017 and December 2019.

Results: The study included 102 patients with a median age of 1 year (IQR, 0.4-3.9) and weight of 9.1 kg (IQR, 4.9-14.2) who received 288 parenteral KCl administrations. One hundred seventy-three administrations were in the 1 mEq/kg group, and 115 administrations were in the 0.5 mEq/kg group. The median changes in K+ were 0.8 and 0.5 mEq/L in the 1 mEq/kg and 0.5 mEq/kg groups, respectively. Patients who had a repeat K+ concentration within 4 hours of the end of a 1 to 2-hour infusion had a higher median change in K+ compared with those who had a concentration drawn after this time frame (0.8 vs 0.6 mEq/L; p < 0.01).

Conclusions: There is a paucity of data on the correlation between parenteral KCl supplementation and change in K+ concentrations in pediatric patients. Our study demonstrated an association between KCl supplementation doses of 1 and 0.5 mEq/kg and changes in K+ of 0.8 and 0.5 mEq/L, respectively, in non-cardiac pediatric patients, with low observed incidence of hyperkalemia.

儿科患者肠外补钾的评价。
目的:主要目的是评估肠外氯化钾(KCl)补充对非心脏儿科人群钾(K+)浓度的影响。次要结果是确定可能影响对KCl补充反应的变量(即KCl给药后K+浓度的变化),并评估高钾血症的发生率。方法:这项单中心回顾性研究评估了2017年1月至2019年12月期间接受0.5或1 mEq/kg肠外补充氯化钾的婴儿和儿童。结果:本研究纳入102例患者,中位年龄为1岁(IQR, 0.4-3.9),体重为9.1 kg (IQR, 4.9-14.2),接受288次肠外KCl治疗。1 mEq/kg组173个用药组,0.5 mEq/kg组115个用药组。在1 mEq/kg和0.5 mEq/kg组中,K+的中位数变化分别为0.8和0.5 mEq/L。在1 - 2小时输注结束后4小时内重复K+浓度的患者,其K+的中位数变化高于在此时间框架后提取浓度的患者(0.8 vs 0.6 mEq/L;P < 0.01)。结论:儿科患者肠外KCl补充与K+浓度变化之间的相关性数据缺乏。我们的研究表明,在高钾血症发生率较低的非心脏儿科患者中,KCl补充剂量为1和0.5 mEq/kg与K+变化分别为0.8和0.5 mEq/L之间存在关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Pediatric Pharmacology and Therapeutics
Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.40
自引率
0.00%
发文量
90
期刊介绍: The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.
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