Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis.

IF 2.4 3区医学 Q2 ANDROLOGY

Basic and Clinical Andrology Pub Date : 2022-12-08 DOI:10.1186/s12610-022-00173-9

Liang Dong, Fang Yang, Junjun Li, Yulin Li, Xujun Yu, Xiaojin Zhang

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引用次数: 0

Abstract

Background: Male fertility has gradually become a worldwide problem with limitations in the treatment. Alpha-lipoic acid, has been applied to improve the quality of sperm in clinical practice. However, there was currently no high quality of systematic review to evaluate the effects of alpha-lipoic acid on sperm parameters.

Material and methods: The Cochrane Library, MEDLINE, EMBASE, Web of Science, Clinicaltrials.org, China National Knowledge Infrastructure Database, China Biology Medicine Database, etc., were retrieved. Related randomized controlled trials had be collected and selected up to March 10, 2022. English literature and Chinese literature were searched using terms including "male infertility", "semen", "sperm", "alpha-lipoid acid", "α-lipoid acid", "alpha lipoid acid", "thioctic acid". All statistical analyses were conducted by RevMan 5.3.

Results: A total of 133 participants in three studies included. Compared with sham therapy, treated with alpha-lipoic acid has significant improvement in the following sperm parameters, including abnormal sperm forms (mean difference[MD] = -1.06, 95% confidence interval [CI] = -1.29-0.84, p < 0.00001), sperm concentration (MD = 3.98, 95%CI = 2.28-5.67, p < 0.00001), sperm total motility (grade a+b+c) (MD = 6.68, 95%CI = 4.88-8.48, p < 0.00001) and progressive motility(grade a+b) (MD = 6.90, 95%CI = 5.62-8.17, p < 0.00001) and semen volume(MD = -0.17, 95%CI = -0.31-0.02, p = 0.03).

Conclusions: In this meta-analysis of three randomized controlled trials, compared with other treatments, alpha-lipoic acid could improve normal sperm forms, sperm concentration, sperm total motility and progressive motility, but more stringent randomized controlled trials must be conducted.

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口服α-硫辛酸（ALA）对精子参数的影响：系统综述和荟萃分析。

背景：男性不育已逐渐成为一个世界性难题，但治疗方法却很有限。在临床实践中，α-硫辛酸已被用于改善精子质量。然而，目前还没有高质量的系统综述来评估α-硫辛酸对精子参数的影响：检索了 Cochrane Library、MEDLINE、EMBASE、Web of Science、Clinicaltrials.org、中国国家知识基础设施数据库、中国生物医学数据库等。收集并筛选了截至 2022 年 3 月 10 日的相关随机对照试验。使用 "男性不育"、"精液"、"精子"、"α-类脂质酸"、"α-类脂质酸"、"α-类脂质酸"、"硫辛酸 "等词检索英文文献和中文文献。所有统计分析均由 RevMan 5.3 进行：三项研究共纳入 133 名参与者。与假治疗相比，使用α-硫辛酸治疗可显著改善精子的以下参数，包括畸形精子（平均差[MD] = -1.06, 95%置信区间[CI] = -1.29-0.84, p 结论：α-硫辛酸治疗可显著改善精子的以下参数，包括畸形精子：在这项对三项随机对照试验的荟萃分析中，与其他治疗方法相比，硫辛酸可改善正常精子形态、精子浓度、精子总活力和渐进活力，但必须进行更严格的随机对照试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Basic and Clinical Andrology Medicine-Urology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.