DEK::AFF2 Fusion Carcinomas of Head and Neck.

IF 5.1 2区医学 Q1 PATHOLOGY

Advances In Anatomic Pathology Pub Date : 2023-03-01 Epub Date: 2022-10-12 DOI:10.1097/PAP.0000000000000376

Komkrit Ruangritchankul, Ann Sandison

引用次数: 4

Abstract

A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. The tumors occurred at multiple sites in the head and neck including in the sinonasal tract, middle ear, and temporal bone. This tumor behaves aggressively involving adjacent vital structures, frequently recurs, and is inclined to develop lymph node and distant metastasis. This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and pattern of molecular alterations as well as to discuss the differential diagnosis of DEK::AFF2 fusion carcinoma.

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DEK:：头颈部AFF2融合癌。

一种新的DEK:：AFF2融合癌最近在29名患者中被描述，这些患者最初表现为非病毒相关的非角化鳞状细胞癌。肿瘤发生在头颈部的多个部位，包括鼻腔、中耳和颞骨。该肿瘤表现为侵袭性侵犯邻近的重要结构，经常复发，并倾向于发展为淋巴结和远处转移。本综述旨在总结DEK:：AFF2融合癌的人口学、临床、病理、免疫表型特征和分子改变模式，并讨论其鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances In Anatomic Pathology 医学-病理学

CiteScore

10.30

自引率

3.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Anatomic Pathology provides targeted coverage of the key developments in anatomic and surgical pathology. It covers subjects ranging from basic morphology to the most advanced molecular biology techniques. The journal selects and efficiently communicates the most important information from recent world literature and offers invaluable assistance in managing the increasing flow of information in pathology.