BDNF-related mutations in major depressive disorder: a systematic review.

IF 3.8 4区 医学 Q1 Medicine
Johannes Hartig, Bogdan Nemeş
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引用次数: 5

Abstract

Objective: A better understanding of the genetic, molecular and cellular mechanisms of brain-derived neurotrophic factor (BDNF) and its association with neuroplasticity could play a pivotal role in finding future therapeutic targets for novel drugs in major depressive disorder (MDD). Because there are conflicting results regarding the exact role of BDNF polymorphisms in MDD still, we set out to systematically review the current evidence regarding BDNF-related mutations in MDD.

Methods: We conducted a keyword-guided search of the PubMed and Embase databases, using 'BDNF' or 'brain-derived neurotrophic factor' and 'major depressive disorder' and 'single-nucleotide polymorphism'. We included all publications in line with our exclusion and inclusion criteria that focused on BDNF-related mutations in the context of MDD.

Results: Our search yielded 427 records in total. After screening and application of our eligibility criteria, 71 studies were included in final analysis. According to present overall scientific data, there is a possibly major pathophysiological role for BDNF neurotrophic systems to play in MDD. However, on the one hand, the synthesis of evidence makes clear that likely no overall association of BDNF-related mutations with MDD exists. On the other hand, it can be appreciated that solidifying evidence emerged on specific significant sub-conditions and stratifications based on various demographic, clinico-phenotypical and neuromorphological variables.

Conclusions: Further research should elucidate specific BDNF-MDD associations based on demographic, clinico-phenotypical and neuromorphological variables. Furthermore, biomarker approaches, specifically combinatory ones, involving BDNF should be further investigated.

重度抑郁症bdnf相关突变:系统综述
目的:深入了解脑源性神经营养因子(BDNF)的遗传、分子和细胞机制及其与神经可塑性的关系,对寻找治疗重度抑郁症(MDD)的新药靶点具有重要意义。由于关于BDNF多态性在MDD中的确切作用的结果仍然相互矛盾,我们开始系统地回顾目前关于MDD中BDNF相关突变的证据。方法:我们使用“BDNF”或“脑源性神经营养因子”、“重度抑郁症”和“单核苷酸多态性”对PubMed和Embase数据库进行了关键词引导搜索。我们纳入了所有符合排除和纳入标准的出版物,这些出版物关注的是MDD背景下bdnf相关突变。结果:我们的搜索总共产生了427条记录。在筛选和应用我们的资格标准后,71项研究被纳入最终分析。根据目前的整体科学数据,BDNF神经营养系统可能在重度抑郁症中发挥重要的病理生理作用。然而,一方面,综合证据表明,bdnf相关突变与重度抑郁症之间可能不存在整体关联。另一方面,可以理解的是,基于各种人口统计学、临床表型和神经形态学变量,在特定的重要亚条件和分层上出现了确凿的证据。结论:进一步的研究应阐明基于人口学、临床表型和神经形态学变量的BDNF-MDD特异性关联。此外,涉及BDNF的生物标志物方法,特别是组合方法应进一步研究。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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