From Malignant Thyroid Teratoma to Thyroblastoma: Evolution of a Newly-recognized DICER1 -associated Malignancy.

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
ACS Applied Materials & Interfaces Pub Date : 2023-03-01 Epub Date: 2022-09-07 DOI:10.1097/PAP.0000000000000364
Lisa M Rooper
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引用次数: 2

Abstract

Thyroblastoma is a novel thyroid malignancy included in the 5th Edition WHO Classification of Endocrine and Neuroendocrine Tumours. The majority of tumors now classified as thyroblastoma were originally regarded to be malignant thyroid teratomas. However, these neoplasms were recently recognized as a separate entity based on a distinctive constellation of primitive multilineage elements, including immature thyroid epithelium, undifferentiated or rhabdomyoblastic spindle cell proliferations, and neuroepithelial blastema, as well as recurrent DICER1 hotspot mutations. Thyroblastoma is an aggressive tumor that leads to death from disease in ~50% of patients, making it essential to differentiate this entity from a wide range of other thyroid tumors that show overlapping histologic features or DICER1 mutations. This review aims to provide a practical overview of the background, clinicopathologic features, molecular underpinnings, and differential diagnosis of this recently-described and molecularly-defined entity.

从甲状腺恶性畸胎瘤到甲状腺母细胞瘤:一种新发现的DICER1相关恶性肿瘤的演变。
甲状腺母细胞瘤是世界卫生组织第5版《内分泌和神经内分泌肿瘤分类》中的一种新型甲状腺恶性肿瘤。现在被归类为甲状腺母细胞瘤的大多数肿瘤最初被认为是恶性甲状腺畸胎瘤。然而,这些肿瘤最近被认为是一个独立的实体,基于一组独特的原始多谱系元素,包括未成熟的甲状腺上皮、未分化或横纹肌母细胞梭形细胞增殖、神经上皮原细胞瘤,以及复发的DICER1热点突变。甲状腺母细胞瘤是一种侵袭性肿瘤,约50%的患者会死于疾病,因此必须将其与其他表现出重叠组织学特征或DICER1突变的甲状腺肿瘤区分开来。这篇综述旨在对这种最近描述和分子定义的实体的背景、临床病理特征、分子基础和鉴别诊断提供一个实用的概述。
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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