Osteosarcoma emboli presenting as chronic thromboembolic pulmonary hypertension in a child.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-02-01 DOI:10.1080/08880018.2022.2053767

Laura L Donahoe, Serina Patel, Soumitra Tole, Alexandra P Zorzi, Lennox Huang, Osami Honjo, Marc de Perrot

引用次数: 1

Abstract

A 13-year-old girl presented with hypoxemia during adjuvant chemotherapy for an osteosarcoma of the left distal femur. She underwent an amputation complicated by a post-operative pulmonary embolism (PE). Three months post-operatively, she was admitted to hospital with severe hypoxemia and diagnosed with pulmonary hypertension on echocardiogram in the context of extensive bilateral PE on computed tomography. She was planned for elective pulmonary thromboendarterectomy, but rapidly deteriorated requiring emergent surgery. At the time of surgery, she was found to have extensive tumor emboli throughout both pulmonary arteries. She recovered well post-operatively but died 2 months later from progressive disease.

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骨肉瘤栓子表现为慢性血栓栓塞性肺动脉高压的儿童。

一个13岁的女孩在左股骨远端骨肉瘤的辅助化疗期间出现低氧血症。她接受了截肢术后并发肺栓塞(PE)。术后3个月，患者因严重低氧血症入院，在超声心动图上诊断为肺动脉高压，同时在计算机断层扫描上显示广泛的双侧PE。她计划择期肺血栓动脉内膜切除术，但病情迅速恶化，需要紧急手术。在手术的时候，她被发现有广泛的肿瘤栓塞在两个肺动脉。患者术后恢复良好，但2个月后因病情进展死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.