Identification of GINS1 as a therapeutic target in the cancer patients infected with COVID-19: a bioinformatics and system biology approach.

IF 2.7 3区生物学

Hereditas Pub Date : 2022-12-01 DOI:10.1186/s41065-022-00258-5

Changpeng Hu, Yue Dai, Huyue Zhou, Jing Zhang, Dandan Xie, Rufu Xu, Mengmeng Yang, Rong Zhang

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引用次数: 1

Abstract

Background: Coronavirus disease 2019 (COVID-19) caused a series of biological changes in cancer patients which have rendered the original treatment ineffective and increased the difficulty of clinical treatment. However, the clinical treatment for cancer patients infected with COVID-19 is currently unavailable. Since bioinformatics is an effective method to understand undiscovered biological functions, pharmacological targets, and therapeutic mechanisms. The aim of this study was to investigate the influence of COVID-19 infection in cancer patients and to search the potential treatments.

Methods: Firstly, we obtained the COVID-19-associated genes from seven databases and analyzed the cancer pathogenic genes from Gene Expression Omnibus (GEO) databases, respectively. The Cancer/COVID-19-associated genes were shown by Venn analyses. Moreover, we demonstrated the signaling pathways and biological functions of pathogenic genes in Cancer/COVID-19.

Results: We identified that Go-Ichi-Ni-San complex subunit 1 (GINS1) is the potential therapeutic target in Cancer/COVID-19 by GEPIA. The high expression of GINS1 was not only promoting the development of cancers but also affecting their prognosis. Furthermore, eight potential compounds of Cancer/COVID-19 were identified from CMap and molecular docking analysis.

Conclusion: We revealed the GINS1 is a potential therapeutic target in cancer patients infected with COVID-19 for the first time, as COVID-19 will be a severe and prolonged pandemic. However, the findings have not been verified actually cancer patients infected with COVID-19, and further studies are needed to demonstrate the functions of GINS1 and the clinical treatment of the compounds.

查看原文本刊更多论文

基于生物信息学和系统生物学方法的新型冠状病毒感染癌症患者GINS1治疗靶点鉴定

背景:2019冠状病毒病(COVID-19)在癌症患者中引起一系列生物学变化，使原有的治疗无效，增加了临床治疗的难度。然而，目前还没有针对感染COVID-19的癌症患者的临床治疗方法。因为生物信息学是了解未被发现的生物功能、药理靶点和治疗机制的有效方法。本研究的目的是探讨COVID-19感染对癌症患者的影响，并寻找潜在的治疗方法。方法:首先从7个数据库中获取covid -19相关基因，并分别从Gene Expression Omnibus (GEO)数据库中分析致癌基因。Venn分析显示了癌症/ covid -19相关基因。此外，我们还展示了Cancer/COVID-19致病基因的信号通路和生物学功能。结果:我们通过GEPIA鉴定出Go-Ichi-Ni-San复合物亚单位1 (GINS1)是Cancer/COVID-19的潜在治疗靶点。GINS1的高表达不仅促进肿瘤的发展，而且影响肿瘤的预后。通过CMap和分子对接分析，鉴定出8个潜在的Cancer/COVID-19化合物。结论:在COVID-19将是一场严重的、长期的大流行的背景下，首次发现GINS1是一种潜在的治疗靶点。然而，这一发现尚未在感染COVID-19的癌症患者中得到验证，需要进一步研究来证明GINS1的功能和化合物的临床治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.