Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine.

IF 3.5 4区医学 Q3 CELL BIOLOGY

Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-02-08 DOI:10.1159/000528346

Eiichi Morii, Yutaka Hatanaka, Noriko Motoi, Akihiko Kawahara, Shinji Hamakawa, Takeshi Kuwata, Tadasuke Nagatomo, Yoshinao Oda, Aikou Okamoto, Ryota Tanaka, Akira Iyoda, Maeda Ichiro, Yukiko Matsuo, Nobuyuki Nakamura, Tokiko Nakai, Mei Fukuhara, Kazuya Tokita, Tomohiko Yamaguchi, Masataka Takenaka, Ayako Kawabata, Kanako C Hatanaka, Kaho Tsubame, Yukitoshi Satoh

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引用次数: 1

Abstract

Rapid advances are being made in cancer drug therapy. Since molecularly targeted therapy has been introduced, personalized medicine is being practiced, pathological tissue from malignant tumors obtained during routine practice is frequently used for genomic testing. Whereas cytological specimens fixed mainly in alcohol are considered to be more advantageous in terms of preservation of the nucleic acid quality and quantity. This article is aimed to share the information for the proper handling of cytological specimens in practice for genomic medicine based on the findings established in "Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine (in Japanese)" published by the Japanese Society of Clinical Cytology in 2021. The three-part practical guidelines are based on empirical data analyses; Part 1 describes general remarks on the use of cytological specimens in cancer genomic medicine, then Part 2 describes proper handling of cytological specimens, and Part 3 describes the empirical data related to handling of cytological specimens. The guidelines indicated proper handling of specimens in each fixation, preparation, and evaluation.

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癌症基因组医学细胞标本处理指南。

癌症药物治疗正在取得迅速进展。自从分子靶向治疗被引入，个性化医学正在实践，在常规实践中获得的恶性肿瘤病理组织经常用于基因组检测。而主要在酒精中固定的细胞学标本被认为在保存核酸质量和数量方面更有利。本文旨在根据日本临床细胞学学会2021年发布的《癌症基因组医学细胞学标本处理指南（日语）》中的研究结果，分享在基因组医学实践中正确处理细胞学标本的信息。三部分实用指南是基于实证数据分析；第1部分描述了在癌症基因组医学中使用细胞学标本的一般说明，第2部分描述了细胞学标本的正确处理，第3部分描述了与细胞学标本处理相关的经验数据。指南指出了在每次固定、制备和评估中对标本的正确处理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathobiology 医学-病理学

CiteScore

8.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.