Development of computational models for microtesla-level magnetic brain scanning: a novel avenue for device development.

Abstract

Background: Detection of locally increased blood concentration and perfusion is critical for assessment of functional cortical activity as well as diagnosis of conditions such as intracerebral hemorrhage (ICH). Current paradigms for assessment of regional blood concentration in the brain rely on computed tomography (CT), magnetic resonance imaging (MRI), and perfusion blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI).

Results: In this study, we developed computational models to test the feasibility of novel magnetic sensors capable of detecting hemodynamic changes within the brain on a microtesla-level. We show that low-field magnetic sensors can accurately detect changes in magnetic flux density and eddy current damping signals resulting from increases in local blood concentration. These models predicted that blood volume changes as small as 1.26 mL may be resolved by the sensors, implying potential use for diagnosis of ICH and assessment of regional blood flow as a proxy for cerebral metabolism and neuronal activity. We then translated findings from our computational model to demonstrate feasibility of accurate detection of modeled ICH in a simulated human cadaver setting.

Conclusions: Overall, microtesla-level magnetic scanning is feasible, safe, and has distinct advantages compared to current standards of care. Computational modeling may facilitate rapid prototype development and testing of novel medical devices with minimal risk to human participants prior to device construction and clinical trials.