Recent Developments and Potential for Clinical Use of Casein as a Drug Carrier.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2023-01-01 DOI:10.2174/1567201819666220513085552

Ravindra Semwal, Sunil Kumar Joshi, Ruchi Badoni Semwal, Deepak Kumar Semwal

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引用次数: 2

Abstract

Background: The development of drug delivery carriers is the key area of research in the field of novel drug delivery systems. To date, a long list of carriers has been identified for this purpose but the deliveries of poorly water-soluble active substances are still facing challenges and hence, such substances are pharmacologically unsafe and economically incompetent.

Objective: This article aims to review the applications of casein as a drug carrier and its potential for clinical use.

Methods: The relevant literature on the casein protein was collected from authentic online scientific databases like PubMed, Scopus and Google Scholar using different keywords including "casein", "drug delivery system", "drug carrier" and "bioavailability". The articles and books accessed online have been thoroughly reviewed and the most relevant reports on casein as a drug carrier have only been included in the present study.

Results: Casein is a milk protein that has many structural and physicochemical properties which facilitate its functionality in delivery systems. Moreover, its amphiphilic nature makes it the most suitable carrier for both hydrophobic and hydrophilic drugs without showing any toxic effects. The carriers obtained from natural sources are trustworthy over synthetic carriers and in the demand of the market due to their easy availability, low-cost factor, bio-friendly and nontoxic nature.

Conclusion: Casein was found to be an effective natural drug carrier in various delivery systems due to its unique applications in improving the bioavailability and efficacy of a drug.

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酪蛋白作为药物载体的最新进展及临床应用潜力。

背景:药物传递载体的开发是新型药物传递系统研究的重点领域。迄今为止，已经为此目的确定了一长列载体，但水溶性差的活性物质的输送仍然面临挑战，因此，这些物质在药理学上不安全，在经济上也不合格。目的:综述酪蛋白作为药物载体的应用及其临床应用潜力。方法:采用“酪蛋白”、“给药系统”、“药物载体”、“生物利用度”等关键词，从PubMed、Scopus、Google Scholar等正版在线科学数据库中检索酪蛋白相关文献。网上的文章和书籍都经过了全面的审查，关于酪蛋白作为药物载体的最相关的报告只包括在本研究中。结果:酪蛋白是一种牛奶蛋白，具有许多结构和物理化学性质，有助于其在输送系统中的功能。此外，它的两亲性使其成为疏水和亲水药物的最合适载体，而不会表现出任何毒性作用。与合成载体相比，天然载体具有易得、低成本、生物友好和无毒等特点，值得信赖。结论:酪蛋白在提高药物的生物利用度和药效方面具有独特的应用价值，是一种有效的天然药物载体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.