Regional cortical hypoperfusion and atrophy correlate with striatal dopaminergic loss in Parkinson's disease: a study using arterial spin labeling MR perfusion.

IF 2.4 3区医学 Q2 CLINICAL NEUROLOGY

Neuroradiology Pub Date : 2023-03-01 DOI:10.1007/s00234-022-03085-7

Yuki Kitazaki, Masamichi Ikawa, Tomohisa Yamaguchi, Soichi Enomoto, Norimichi Shirafuji, Osamu Yamamura, Tetsuya Tsujikawa, Hidehiko Okazawa, Hirohiko Kimura, Yasunari Nakamoto, Tadanori Hamano

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引用次数: 1

Abstract

Purpose: To investigate the relationship of the striatal dopamine transporter density to changes in the gray matter (GM) volume and cerebral perfusion in patients with Parkinson's disease (PD).

Methods: We evaluated the regional cerebral blood flow (CBF) and GM volume, concurrently measured using arterial spin labeling and T1-weighted magnetic resonance imaging, respectively, as well as the striatal specific binding ratio (SBR) in ¹²³I-N-ω-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (¹²³I-FP-CIT) single-photon emission computed tomography in 30 non-demented patients with PD (15 men and 15 women; mean age, 67.2 ± 8.8 years; mean Hoehn-Yahr stage, 2.2 ± 0.9). Voxel-wise regression analyses using statistical parametric mapping (SPM) were performed to explore the brain regions that showed correlations of the striatal SBR to the GM volume and CBF, respectively, with a height threshold of p < 0.0005 at the voxel level and p < 0.05 family-wise error-corrected at the cluster level.

Results: SPM analysis showed a significant positive correlation between the SBR and GM volume in the inferior frontal gyrus (IFG). Whereas, a positive correlation between the SBR and CBF was widely found in the frontotemporal and parietotemporal regions, including the IFG. Notably, the opercular part of the IFG showed significant correlations in both SPM analyses of the GM volume (r² = 0.90, p < 0.0001) and CBF (r² = 0.88, p < 0.0001).

Conclusion: The voxel-wise analyses revealed the brain regions, mainly the IFG, that showed hypoperfusion and atrophy related to dopaminergic loss, which suggests that the progression of dopaminergic neurodegeneration leads to regional cortical dysfunction in PD.

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区域皮质灌流不足和萎缩与帕金森病纹状体多巴胺能损失相关:一项动脉自旋标记MR灌注的研究

目的:探讨帕金森病(PD)患者纹状体多巴胺转运体密度与灰质(GM)体积和脑灌注变化的关系。方法:我们评估了30例非痴呆PD患者(男15例、女15例;平均年龄67.2±8.8岁;平均Hoehn-Yahr分期，2.2±0.9)。采用统计参数映射(SPM)进行体素回归分析，分别探索纹状体SBR与GM体积和CBF相关的脑区，高度阈值为p。结果:SPM分析显示，额下回(IFG)的SBR和GM体积之间存在显著的正相关。然而，SBR和CBF之间的正相关被广泛发现在额颞叶和顶颞叶区域，包括IFG。值得注意的是，在两种SPM分析中，IFG的眼窝部分显示出显著的相关性(r2 = 0.90, p 2 = 0.88, p)。结论:体素分析显示，大脑区域，主要是IFG，表现出与多巴胺能损失有关的灌注不足和萎缩，这表明多巴胺能神经退行性进展导致PD的区域皮质功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.