Geriatric syndromes, chronic inflammation, and advances in the management of frailty: A review with new insights.

IF 5.7 4区生物学 Q1 BIOLOGY

Bioscience trends Pub Date : 2023-09-15 Epub Date: 2023-08-23 DOI:10.5582/bst.2023.01184

Niuniu Li, Gaolin Liu, Hong Gao, Qiang Wu, Juan Meng, Fei Wang, Siwei Jiang, Meixia Chen, Wenhui Xu, Yifan Zhang, Yanjun Wang, Yingqian Feng, Juncai Liu, Cheng Xu, Hongzhou Lu

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引用次数: 0

Abstract

As people age, geriatric syndromes characterized by frailty significantly impact both clinical practice and public health. Aging weakens people's immune functions, leading to chronic low-grade inflammation that ultimately contributes to the development of frailty. Effectively managing geriatric syndromes and frailty can help alleviate the economic burden of an aging population. This review delves into the intricate relationship among aging, infection-induced inflammation, chronic inflammation, and frailty. In addition, it analyzes various approaches and interventions to address frailty, such as smart rehabilitation programs and stem-cell treatments, offering promising solutions in this new era. Given the importance of this topic, further research into the mechanisms of frailty is crucial. Equally essential is the devising of relevant measures to delay its onset and the formulation of comprehensive clinical, research, and public health strategies to enhance the quality of life for elderly individuals.

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老年综合征、慢性炎症和虚弱治疗进展：一篇有新见解的综述。

随着人们年龄的增长，以虚弱为特征的老年综合征会对临床实践和公共卫生产生重大影响。衰老削弱了人们的免疫功能，导致慢性低度炎症，最终导致虚弱的发展。有效管理老年综合征和虚弱有助于减轻老龄化人口的经济负担。这篇综述深入探讨了衰老、感染引起的炎症、慢性炎症和虚弱之间的复杂关系。此外，它还分析了解决虚弱的各种方法和干预措施，如智能康复计划和干细胞治疗，为这个新时代提供了有前景的解决方案。鉴于这一主题的重要性，进一步研究虚弱的机制至关重要。同样重要的是制定相关措施以延缓其发病，并制定全面的临床、研究和公共卫生战略，以提高老年人的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience trends BIOLOGY-

CiteScore

13.60

自引率

1.80%

发文量

审稿时长

>12 weeks

期刊介绍： BioScience Trends (Print ISSN 1881-7815, Online ISSN 1881-7823) is an international peer-reviewed journal. BioScience Trends devotes to publishing the latest and most exciting advances in scientific research. Articles cover fields of life science such as biochemistry, molecular biology, clinical research, public health, medical care system, and social science in order to encourage cooperation and exchange among scientists and clinical researchers.