Updated insight into the characterization of nano-emulsions.

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Xinyue Wang, Halina Anton, Thierry Vandamme, Nicolas Anton
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引用次数: 2

Abstract

Introduction: In most of the studies, nano-emulsion characterization is limited to their size distribution and zeta potential. In this review, we present an updated insight of the characterization methods of nano-emulsions, including new or unconventional experimental approaches to explore in depth the nano-emulsion properties.

Area covered: We propose an overview of all the main techniques used to characterize nano-emulsions, including the most classical ones, up to in vitro, ex vivo and in vivo evaluation. Innovative approaches are then presented in the second part of the review that presents innovative, experimental techniques less known in the field of nano-emulsion such as the nanoparticle tracking analysis, small-angle X-ray scattering, Raman spectroscopy, and nuclear magnetic resonance. Finally, in the last part we discuss the use of lipophilic fluorescent probes and imaging techniques as an emerging tool to understand the nano-emulsion droplet stability, surface decoration, release mechanisms, and in vivo fate.

Expert opinion: This review is mostly intended for a broad readership and provides key tools regarding the choice of the approach to characterize nano-emulsions. Innovative and uncommon methods will be precious to disclose the information potentially reachable behind a formulation of nano-emulsions, not always known in first intention and with conventional methods.

对纳米乳液表征的最新见解。
在大多数研究中,纳米乳液的表征仅限于它们的尺寸分布和zeta电位。在这篇综述中,我们介绍了纳米乳液表征方法的最新见解,包括新的或非常规的实验方法来深入探索纳米乳液的性质。涵盖领域:我们概述了用于表征纳米乳液的所有主要技术,包括最经典的技术,直到体外,离体和体内评估。本文的第二部分介绍了一些创新的方法,这些创新的实验技术在纳米乳液领域鲜为人知,如纳米颗粒跟踪分析、小角度x射线散射、拉曼光谱和核磁共振。最后,在最后一部分,我们讨论了使用亲脂性荧光探针和成像技术作为新兴工具来了解纳米乳液滴的稳定性、表面修饰、释放机制和体内命运。专家意见:这篇综述主要是为广大读者准备的,并提供了关于纳米乳液表征方法选择的关键工具。创新和不寻常的方法对于揭示纳米乳液配方背后可能获得的信息将是宝贵的,这些信息在最初的意图和传统的方法中并不总是已知的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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