Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles.

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Mahmoud Abdelkarim, Luis Perez-Davalos, Yasmin Abdelkader, Amr Abostait, Hagar I Labouta
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引用次数: 2

Abstract

Introduction: Organ-on-a-chip (OOC) models are based on microfluidics and can recapitulate the healthy and diseased microstructure of organs1 and tissues and the dynamic microenvironment inside the human body. However, the use of OOC models to evaluate the safety and efficacy of nanoparticles (NPs) is still in the early stages.

Areas covered: The different design parameters of the microfluidic chip and the mechanical forces generated by fluid flow play a pivotal role in simulating the human environment. This review discusses the role of different key parameters on the performance of OOC models. These include the flow pattern, flow rate, shear stress (magnitude, rate, and distribution), viscosity of the media, and the microchannel dimensions and shape. We also discuss how the shear stress and other mechanical forces affect the transport of NPs across biological barriers, cell uptake, and their biocompatibility.

Expert opinion: We describe several good practices and design parameters to consider for future OOC research. We submit that following these recommendations will help realize the full potential of the OOC models in the preclinical evaluation of novel therapies, including NPs.

开发仿生器官芯片模型的关键设计参数,用于评估纳米颗粒的安全性和有效性。
器官芯片(Organ-on-a-chip, OOC)模型是一种基于微流控学的模型,能够再现人体器官和组织健康和病变的微观结构,以及人体内部的动态微环境。然而,使用OOC模型来评估纳米颗粒(NPs)的安全性和有效性仍处于早期阶段。涉及领域:微流控芯片的不同设计参数和流体流动产生的机械力在模拟人类环境中起着关键作用。本文讨论了不同关键参数对OOC模型性能的影响。这些参数包括流态、流速、剪切应力(大小、速率和分布)、介质粘度以及微通道的尺寸和形状。我们还讨论了剪切应力和其他机械力如何影响NPs跨越生物屏障的运输、细胞摄取及其生物相容性。专家意见:我们描述了几个良好的实践和设计参数,以供将来的OOC研究考虑。我们认为,遵循这些建议将有助于实现OOC模型在包括NPs在内的新疗法的临床前评估中的全部潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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